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Titolo:
SPLICING FACTOR SF3A60 IS THE MAMMALIAN HOMOLOG OF PRP9 OF SACCHAROMYCES-CEREVISIAE - THE CONSERVED ZINC FINGER-LIKE MOTIF IS FUNCTIONALLY EXCHANGEABLE IN-VIVO
Autore:
KRAMER A; LEGRAIN P; MULHAUSER F; GRONING K; BROSI R; BILBE G;
Indirizzi:
UNIV GENEVA,DEPT BIOL CELLULAIRE,30 QUAI ERNEST ANSERMET CH-1211 GENEVA 4 SWITZERLAND INST PASTEUR,DEPT BIOL MOLEC F-75724 PARIS 15 FRANCE CIBA GEIGY LTD,DEPT MOLEC & CELL BIOL,PHARMA RES CH-4002 BASEL SWITZERLAND
Titolo Testata:
Nucleic acids research
fascicolo: 24, volume: 22, anno: 1994,
pagine: 5223 - 5228
SICI:
0305-1048(1994)22:24<5223:SFSITM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL NUCLEAR RIBONUCLEOPROTEIN; PRE-MESSENGER-RNA; U2 SNRNP BINDING; INTEGRAL COMPONENT; PREMESSENGER RNA; YEAST PRP9; PROTEINS; PURIFICATION; COMPLEX; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A. Kramer et al., "SPLICING FACTOR SF3A60 IS THE MAMMALIAN HOMOLOG OF PRP9 OF SACCHAROMYCES-CEREVISIAE - THE CONSERVED ZINC FINGER-LIKE MOTIF IS FUNCTIONALLY EXCHANGEABLE IN-VIVO", Nucleic acids research, 22(24), 1994, pp. 5223-5228

Abstract

A cDNA encoding the 60 kDa subunit of mammalian splicing factor SF3a has been isolated. The deduced protein sequence reveals a 30% identityto the PRP9 splicing protein of the yeast S.cerevisiae. The highest homology is present in a zinc finger-like region in the C-terminal domain of both proteins. the PRP9 zinc finger-like motif has been replacedby the equivalent region of mammalian SF3a60. The chimeric protein rescues the temperature-sensitive phenotype of the prp9-1 mutant strain demonstrating that not only the structure but also the function of this domain has been conserved during evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:30:23