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Titolo:
RAPID ACTIVATION OF THE INTERFERON-GAMMA SIGNAL-TRANSDUCTION PATHWAY BY INHIBITORS OF TYROSINE PHOSPHATASES
Autore:
LAMB P; HASLAM J; KESSLER L; SEIDEL HM; STEIN RB; ROSEN J;
Indirizzi:
LIGAND PHARMACEUT,9393 TOWNE CTR DR,SUITE 100 SAN DIEGO CA 92121
Titolo Testata:
Journal of interferon research
fascicolo: 6, volume: 14, anno: 1994,
pagine: 365 - 373
SICI:
0197-8357(1994)14:6<365:RAOTIS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING PROTEINS; TRANSCRIPTION FACTOR; GROWTH-FACTOR; REGULATORY FACTOR; STIMULATED GENES; IFN-GAMMA; VANADATE; PHOSPHORYLATION; KINASE; ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
P. Lamb et al., "RAPID ACTIVATION OF THE INTERFERON-GAMMA SIGNAL-TRANSDUCTION PATHWAY BY INHIBITORS OF TYROSINE PHOSPHATASES", Journal of interferon research, 14(6), 1994, pp. 365-373

Abstract

Induction of gene expression by interferon-gamma involves the activation of a latent cytoplasmic transcription factor, p91, by phosphorylation on a single tyrosyl residue, This phosphorylation triggers dimerization, nuclear translocation, and the binding of p91 to interferon-gamma response elements present in the promoters of induced genes, Phosphorylation of p91 requires the activation of two tyrosine kinases, JAK1and JAK2, that themselves become phosphorylated on tyrosyl residues shortly after interferon-gamma binds to its receptor, The importance oftyrosine phosphorylation in this pathway prompted us to investigate the role of protein tyrosine phosphatases in the regulation of the pathway, We find that in the absence of interferon-gamma, treatment of cells with an inhibitor of tyrosine phosphatases causes a rapid and potent activation of the components of the interferon-gamma signal transduction pathway and induces an interferon-gamma-responsive gene. This suggests that tyrosine phosphatases act both to repress the interferon-gamma signal transduction pathway in the absence of interferon-gamma andto downregulate the pathway after interferon-gamma induction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:27:14