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Titolo:
ACUTE VIRAL RESPIRATORY-TRACT INFECTIONS AND CHILDHOOD ASTHMA - EPIDEMIOLOGIC, IMMUNOPATHOLOGICAL AND THERAPEUTIC ASPECTS
Autore:
REFABERT L; DEBLIC J; SCHEINMANN P;
Indirizzi:
HOP NECKER ENFANTS MALAD,SERV PNEUMOL & ALLERGOL PEDIAT,149 RUE SEVRES F-75730 PARIS 15 FRANCE
Titolo Testata:
Revue francaise d'allergologie et d'immunologie clinique
fascicolo: 7, volume: 36, anno: 1996,
pagine: 775 - 781
SICI:
0335-7457(1996)36:7<775:AVRIAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
FRE
Soggetto:
EPITHELIAL-CELL LINE; RHINOVIRUS COLDS; NONALLERGIC SUBJECTS; NASAL SECRETIONS; VIRUS; CHILDREN; PRECIPITANTS; INFLAMMATION; INTERFERON; SYMPTOMS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
L. Refabert et al., "ACUTE VIRAL RESPIRATORY-TRACT INFECTIONS AND CHILDHOOD ASTHMA - EPIDEMIOLOGIC, IMMUNOPATHOLOGICAL AND THERAPEUTIC ASPECTS", Revue francaise d'allergologie et d'immunologie clinique, 36(7), 1996, pp. 775-781

Abstract

Respiratory viral infections are very important triggers of asthma exacerbation. Recent epidemiologic studies support the hypothesis that they are associated with 80 to 85 % of acute attacks of asthma in children, both in mild exacerbations, and in more severe exacerbations leading to hospital admission. The respiratory syncytial and parainfluenzaviruses are predominantly detected in infants, while rhinovirus and mycoplasma are the commonest viruses in children. The detailed mechanism of virus-induced exacerbations remains poorly understood, although recent studies have provided evidence of increased activation of inflammation, cells in bronchial lavage. Allergic individuals, outside of periods of allergy, do not seem to have more virus-induced respiratory manifestations than nonallergic individuals. In contrast, rhinovirus infection may intensify both the immediate and late response to allergenchallenge by increasing mast cell mediator release and recruitment ofeosinophils in the lower airways, human and animal studies suggest that local production of cytokines (IL4, IL8, RANTES, MIP-1a...) and theincreased expression of intercellular adhesion molecule 1 (ICAM1) in asthmatic individuals, may play an important role for recruitment and activation of inflammatory cells in the airways. One hypothesis, that remains to bet demonstrated, would be that in the presence of Th2 predominance, as occurs in asthma, an excess of IL4 could inhibit the development of cytotoxic CD8, NK and Th1 activity, thereby resulting in decreased IFN production, more severe allergic inflammation and less efficient viral clearance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:34:32