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Titolo:
HETEROGENEITY OF EPSTEIN-BARR-VIRUS INFECTION IN ANGIOIMMUNOBLASTIC LYMPHADENOPATHY TYPE T-CELL LYMPHOMA
Autore:
OHSHIMA K; TAKEO H; KIKUCHI M; KOZURU M; UIKE N; MASUDA Y; YONEDA S; TAKESHITA M; SHIBATA T; AKAMATSU M;
Indirizzi:
FUKUOKA UNIV,SCH MED,DEPT PATHOL,JYONAN KU,NANAKUMA 7-45-1 FUKUOKA 81401 JAPAN KYUSHU CANC CTR HOSP,HAEMATOL SECT FUKUOKA JAPAN
Titolo Testata:
Histopathology
fascicolo: 6, volume: 25, anno: 1994,
pagine: 569 - 579
SICI:
0309-0167(1994)25:6<569:HOEIIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; ANGIO-IMMUNOBLASTIC LYMPHADENOPATHY; HODGKINS-DISEASE; LYMPHOPROLIFERATIVE DISORDERS; LYMPHOEPITHELIOID LYMPHOMA; MALIGNANT-LYMPHOMA; VIRAL GENOMES; ZONE LYMPHOMA; LOW-GRADE; DNA;
Keywords:
ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINEMIA; EPSTEIN-BARR VIRUS; LATENT MEMBRANE PROTEIN; EPSTEIN-BARR VIRUS ENCODED RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
K. Ohshima et al., "HETEROGENEITY OF EPSTEIN-BARR-VIRUS INFECTION IN ANGIOIMMUNOBLASTIC LYMPHADENOPATHY TYPE T-CELL LYMPHOMA", Histopathology, 25(6), 1994, pp. 569-579

Abstract

To investigate the relationship of Epstein-Barr virus (EBV) and angioimmunoblastic lymphadenopathy with dysproteinemia, we performed DNA analysis using the polymerase chain reaction (PCR), Southern blot, in situ hybridization, and immunohistochemical analysis of lymph nodes in five patients who were followed up and biopsied more than once. In the course of the disease, nodal architecture diminished, cellular atypia worsened, and clear cells increased in number. In the DNA analysis of the receptor genes, the clonal population increased in number. EBV nucleic acid sequences were found by either PCR or in situ hybridization in all examined nodes. The number of EBV-positive cells varied widely among the cases and throughout the course of the disease in the same patients. The analysis of EBV terminal repeats or lymphocyte-determinedmembrane antigen genes showed polyclonal populations of EB-infected cells. EBV-positive cells possessed intermediate- to large-sized nuclei, and the cells with large nuclei, especially, expressed latent membrane protein of EBV. These large cells varied in number among the cases. Double-labelling immunohistochemistry/in situ hybridization studies demonstrated that most of the EBV-positive cells expressed B-cell antigen (CD20). The presence of EBV seems to be associated with the selective defects of the immune system, rather than with the direct pathogenesis of angioimmunoblastic lymphadenopathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:02:08