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Titolo:
P-ELEMENT-INDUCED VARIATION IN METABOLIC-REGULATION IN DROSOPHILA
Autore:
CLARK AG; WANG L; HULLEBERG T;
Indirizzi:
PENN STATE UNIV,DEPT BIOL,208 MUELLER LAB UNIVERSITY PK PA 16802
Titolo Testata:
Genetics
fascicolo: 1, volume: 139, anno: 1995,
pagine: 337 - 348
SICI:
0016-6731(1995)139:1<337:PVIMID>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESTRICTION-MAP VARIATION; MUTATION-SELECTION BALANCE; ACHAETE-SCUTE REGION; QUANTITATIVE VARIATION; NATURAL-POPULATIONS; STABILIZING SELECTION; PHENOTYPIC VARIATION; POLYGENIC MUTATION; MELANOGASTER; ZESTE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Clark et al., "P-ELEMENT-INDUCED VARIATION IN METABOLIC-REGULATION IN DROSOPHILA", Genetics, 139(1), 1995, pp. 337-348

Abstract

Movement of transposable elements has been demonstrated to be a causeof genetic variation that is relevant to quantitative characters in Drosophila. Here a particular class of P-element-induced variation known to be mediated through changes in expression of targeted enzyme-encoding genes is examined. Balancer chromosomes and the ''jumpstarter'' modified P-element were used to construct 124 second-chromosome and 139third-chromosome lines of Drosophila melanogaster bearing unique stable P-element insertions in a common genetic background. Lines that were homozygous for second-chromosome P-element insertions were significantly more heterogeneous than control lines in 10 of 16 characters, whereas third-chromosome insertion lines were heterogeneous in 11 of the 16 traits. The average mutational variance per insertion relative to environmental variance (V-m\1/V-e) was 5.7 x 10(-2), and estimates varied widely across characters. The distributions of mutational effects tended to be skewed, with a longer tail toward high enzyme activities. Mutational effects deviated from a normal distribution in 15 of the 16traits and significant outlier lines were found in both a positive and negative direction in several characters. Pleiotropic effects of single P-element insertions were quantified by correlation, and, after correcting for simultaneous tests, of the 91 correlations, 37 were significant at the 5% level. The pattern of pleiotropic effects deviated both from the equilibrium genetic correlations quantified in a previous study and from the correlations of mutational effects in a mutation-accumulation experiment, suggesting that multiple forces are at pig thatshape extant variation.

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Documento generato il 30/11/20 alle ore 10:19:44