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Titolo:
THE EFFECTS OF LEVOSULPIRIDE ON GASTRIC AND GALLBLADDER EMPTYING IN FUNCTIONAL DYSPEPSIA
Autore:
ARIENTI V; CORAZZA GR; SORGE M; BORIANI L; UGENTI F; BIAGI F; MACONI G; SOTTILI S; VANTHIEL DH; GASBARRINI G;
Indirizzi:
UNIV BOLOGNA,POLICLIN S ORSOLA,VIA MASSARENTI 9 I-40138 BOLOGNA ITALY UNIV BOLOGNA,POLICLIN S ORSOLA I-40138 BOLOGNA ITALY UNIV AQUILA,DIPARTIMENTO MED INTERNA LAQUILA ITALY OKLAHOMA TRANSPLANTAT INST OKLAHOMA CITY OK 00000
Titolo Testata:
Alimentary pharmacology & therapeutics
fascicolo: 6, volume: 8, anno: 1994,
pagine: 631 - 638
SICI:
0269-2813(1994)8:6<631:TEOLOG>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTAL STOMACH; LIQUID MEAL; MOTILITY; SOLIDS; CISAPRIDE; SULPIRIDE; HUMANS; TIME; METOCLOPRAMIDE; DOMPERIDONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
V. Arienti et al., "THE EFFECTS OF LEVOSULPIRIDE ON GASTRIC AND GALLBLADDER EMPTYING IN FUNCTIONAL DYSPEPSIA", Alimentary pharmacology & therapeutics, 8(6), 1994, pp. 631-638

Abstract

Background: 50% of patients with functional dyspepsia have delayed gastric emptying. Levosulpiride is an orthopramide drug that stimulates gastrointestinal motility. Aim of our study was to evaluate the effectof levosulpiride on symptoms and gastric and gall-bladder emptying, in dyspeptic patients. Methods: Thirty adult patients, treated for 20 days with levosulpiride (75 mg/day) or placebo, were evaluated in a randomized double-blind study. Symptoms were assessed by a cumulative index and overall intensity (visual analogue line). Gastric and gall-bladder emptying were evaluated by epigastric impedance (liquid meal) and real-time ultrasonography (mixed meal). Results: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P < 0.05), gastric emptying (P < 0.001 at 180 min; P < 0.05 at 240 min), and gall-bladder emptying (P < 0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal. Both the mean cumulative index (P < 0.05) and the overall intensity (P < 0.025) of dyspeptic symptomswere reduced significantly by levosulpiride. Conclusions: Our resultsshowed that levosulpiride can be usefully employed in patients affected by functional dyspepsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:51:34