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Titolo:
INJECTION OF RAMIPRIL INTO THE LATERAL VENTRICLE INTERFERES WITH THE DRINKING RESPONSE INDUCED BY PHARMACOLOGICAL AND NATURAL THIRST STIMULI
Autore:
SAAD WA; LUIZ AC; CAMARGO LAA; MENANI JV; RENZI A; SILVEIRA JEN; PAULINO MA; SAAD WA;
Indirizzi:
UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,RUA HUMAITA 1680 BR-14801903 ARARAQUARA SP BRAZIL UNIV SAO PAULO,FAC MED,DEPT CIRURGIA BR-01246903 SAO PAULO BRAZIL
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 12, volume: 27, anno: 1994,
pagine: 2909 - 2913
SICI:
0100-879X(1994)27:12<2909:IORITL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; INHIBITION; RAT; INVITRO;
Keywords:
RAMIPRIL; CENTRAL NERVOUS SYSTEM; ANGIOTENSIN; WATER INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
W.A. Saad et al., "INJECTION OF RAMIPRIL INTO THE LATERAL VENTRICLE INTERFERES WITH THE DRINKING RESPONSE INDUCED BY PHARMACOLOGICAL AND NATURAL THIRST STIMULI", Brazilian journal of medical and biological research, 27(12), 1994, pp. 2909-2913

Abstract

We investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (icv) injection of ramipril (1 mu g/mu l) significantly reduced drinking in response to subcutaneous (sc) injection of isoprenaline (100 mu g/kg) from 8.49 +/- 0.69 to 2.96 +/- 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 +/- 2.20 to 1.6 +/- 0.34 ml/2 h or water deprivation for 24 h from 12.61 +/- 0.83 to 5.10 +/- 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellulardehydration produced by sc injection of hypertonic saline (2 M NaCl). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril istransformed to ramiprilat, the active drug, by the brain is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:34:27