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Titolo:
THYRSIFERYL 23-ACETATE IS A NOVEL SPECIFIC INHIBITOR OF PROTEIN PHOSPHATASE PP2A
Autore:
MATSUZAWA S; SUZUKI T; SUZUKI M; MATSUDA A; KAWAMURA T; MIZUNO Y; KIKUCHI K;
Indirizzi:
HOKKAIDO UNIV,INST IMMUNOL SCI,BIOCHEM SECT,KITA KU,KITA-15,NISHI-7 SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,CHEM LAB KUSHIRO 085 JAPAN HOKKAIDO UNIV,GRAD SCH ENVIRONM EARTH SCI,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 2-3, volume: 356, anno: 1994,
pagine: 272 - 274
SICI:
0014-5793(1994)356:2-3<272:T2IANS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT SKELETAL-MUSCLE; MRL/MPJ-LPR/LPR MICE; OKADAIC ACID; POTENT INHIBITOR; LYMPHOID-TISSUES; MICROCYSTIN-LR; PURIFICATION; TAUTOMYCIN; TYPE-1; KINASE;
Keywords:
THYRSIFERYL 23-ACETATE; PROTEIN PHOSPHATASE 2A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S. Matsuzawa et al., "THYRSIFERYL 23-ACETATE IS A NOVEL SPECIFIC INHIBITOR OF PROTEIN PHOSPHATASE PP2A", FEBS letters, 356(2-3), 1994, pp. 272-274

Abstract

Thyrsiferyl 23-acetate (TF23A), a cytotoxic compound from marine red alga, has been shown to potently and specifically inhibit serine/threonine protein phosphatase 2A (PP2A) with IC50 values of 4-16 mu M, depending on the enzyme concentration. TF23A did not affect activity of protein phosphatase 1 (PP1), 2B (PP2B), 2C (PP2C), or protein tyrosine phosphatases (PTP) up to 1 mM. It inhibited PP2A activity in a crude extract of a human T cell line, Jurkat cell, as well as the purified catalytic subunit. Thus, TF23A proved to be a novel useful probe for clearly distinguishing the activity of PP2A from those of the other protein phosphatases in crude cell extracts and identification of cellular processes that are regulated by PP2A.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 03:15:20