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Titolo:
PROSPECTIVE RANDOMIZED STUDY ON THE CRYOPRESERVATION OF HUMAN EMBRYOSWITH DIMETHYLSULFOXIDE OR 1,2-PROPANEDIOL PROTOCOLS
Autore:
VANDERELST J; CAMUS M; VANDENABBEEL E; MAES R; DEVROEY P; VANSTEIRTEGHEM AC;
Indirizzi:
FREE UNIV BRUSSELS,SCH MED,CTR REPROD MED,LAARBEEKLAAN 101 B-1090 BRUSSELS BELGIUM ERASME UNIV HOSP B-1070 BRUSSELS BELGIUM
Titolo Testata:
Fertility and sterility
fascicolo: 1, volume: 63, anno: 1995,
pagine: 92 - 100
SICI:
0015-0282(1995)63:1<92:PRSOTC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVITRO FERTILIZATION; PREGNANCY; SUCCESS; VIABILITY; GAMETE; RATES;
Keywords:
CRYOPRESERVATION; HUMAN; EMBRYOS; SURVIVAL; IMPLANTATION; PREGNANCY; DIMETHYL SULFOXIDE; 1,2-PROPANEDIOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J. Vanderelst et al., "PROSPECTIVE RANDOMIZED STUDY ON THE CRYOPRESERVATION OF HUMAN EMBRYOSWITH DIMETHYLSULFOXIDE OR 1,2-PROPANEDIOL PROTOCOLS", Fertility and sterility, 63(1), 1995, pp. 92-100

Abstract

Objective: To investigate the optimal protocol for cryopreservation of human embryos obtained from IVF. Design: Prospective randomized study. Setting: Consenting patients in an academic research environment. Patients: Couples undergoing IVF. Interventions: A cohort of 2,220 supernumerary multicellular embryos were obtained from 488 patients who were randomized over slow freezing protocols with dimethylsulfoxide (DMSO, 819 embryos), 1,2-propanediol (699 embryos) or a mixture of DMSO and 1,2-propanediol (702 embryos). A total of 725 embryos have been thawed (DMSO, 232 embryos; 1,2-propanediol, 250 embryos and DMSO and 1,2-propanediol, 243 embryos) for transfer in natural ovarian cycles. Main Outcome Measures: Embryo survival rate, embryo implantation rate, clinical pregnancy rate (PR), delivery rate, live-birth rate. Results: Theembryo survival rate was significantly higher with the DMSO protocol (52.6%) than with the 1,2-propanediol (32.0%) or the DMSO and 1,2-propanediol protocols (34.9%). The clinical PR per thawing cycle was significantly higher in the DMSO protocol (17.2%) than in the 1,2-propanediol protocol (3.9%). The clinical implantation rate per embryo thawed was significantly different between a DMSO-frozen embryo (4.7%) and a 1,2-propanediol-frozen embryo (1.2%). A DMSO and 1,2-propanediol-frozenembryo had a 3.7% chance of implantation. The delivery rate per thawing cycle was significantly higher in the DMSO protocol (12.5%) than inthe 1,2-propanediol protocol (2.6%). The live-birth rates per embryo thawed were 3.5%, 0.8%, and 2.9% in the DMSO, 1,2-propanediol, and DMSO and 1,2-propanediol groups, respectively. Conclusion: Supernumerary multicellular embryos as presented in daily clinical IVF practice havethe highest chance of survival and of implantation after cryopreservation when DMSO has been used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:15:51