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Titolo:
MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF A MOUSE CYTOCHROME-P-450 (CYP3A-13) - EXAMINATION OF CYP3A-13 ENZYME TO ACTIVATE AFLATOXIN B-1 (AFB(1))
Autore:
YANAGIMOTO T; ITOH S; SAWADA M; HASHIMOTO H; KAMATAKI T;
Indirizzi:
HOKKAIDO UNIV,FAC PHARMACEUT SCI,DIV DRUG METAB,KITA KU,N12W6 SAPPOROHOKKAIDO 060 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI,DIV DRUG METAB,KITA KU SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
Biochimica et biophysica acta (G). General subjects
fascicolo: 3, volume: 1201, anno: 1994,
pagine: 405 - 410
SICI:
0304-4165(1994)1201:3<405:MAFEOA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LIVER; NIFEDIPINE OXIDASE; STABLE EXPRESSION; COMPLETE CDNA; FETAL LIVERS; SEQUENCE; AFLATOXIN-B1; GENE; ACID; ACTIVATION;
Keywords:
AFLATOXIN B-1; CDNA CLONING; CHL CELL; CYP3A; CYTOCHROME P-450; CYTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Yanagimoto et al., "MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF A MOUSE CYTOCHROME-P-450 (CYP3A-13) - EXAMINATION OF CYP3A-13 ENZYME TO ACTIVATE AFLATOXIN B-1 (AFB(1))", Biochimica et biophysica acta (G). General subjects, 1201(3), 1994, pp. 405-410

Abstract

A cDNA encoding a novel member of the cytochrome P-450 superfamily, Cyp3a-13, has been isolated from mouse liver cDNA library by hybridization screening. The Cyp3a-13 encoded 503 amino acid residues and shared71% amino acid identity with Cyp3a-11. When Cyp3 alpha-13 cDNA was expressed in CR119 cells which had been established as a cell line stably expressing NADPH-cytochrome P-450 reductase cDNA of guinea pigs, aflatoxin B-1-dependent cytotoxicity was observed. This cytotoxicity was enhanced by alpha-naphthoflavone (7,8-benzoflavone), which is known toaugment the CYP3A enzymatic activity. The results indicate that CYP3Ain mice, which are relatively insensitive to aflatoxin B-1, can activate aflatoxin B-1 to a genotoxic product.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:20:42