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Titolo:
NEUROPROTECTIVE ACTIVITY OF HU-211, A NOVEL NMDA ANTAGONIST, IN GLOBAL-ISCHEMIA IN GERBILS
Autore:
BARJOSEPH A; BERKOVITCH Y; ADAMCHIK J; BIEGON A;
Indirizzi:
PHARMOS CORP IL-76326 REHOVOT ISRAEL
Titolo Testata:
Molecular and chemical neuropathology
fascicolo: 2-3, volume: 23, anno: 1994,
pagine: 125 - 135
SICI:
1044-7393(1994)23:2-3<125:NAOHAN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ISCHEMIA; NEURONAL DAMAGE; BRAIN-DAMAGE; ASPARTATE; MK-801; HIPPOCAMPUS; RECEPTOR; RAT; HYPOTHERMIA; GLUTAMATE;
Keywords:
BRAIN ISCHEMIA; GERBILS; HU-211; NMDA; NEUROPROTECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Barjoseph et al., "NEUROPROTECTIVE ACTIVITY OF HU-211, A NOVEL NMDA ANTAGONIST, IN GLOBAL-ISCHEMIA IN GERBILS", Molecular and chemical neuropathology, 23(2-3), 1994, pp. 125-135

Abstract

HU-211, a nonpsychotropic cannabinoid and a noncompetitive NMDA antagonist, was tested in a global ischemia model in the Mongolian gerbil. Male Mongolian gerbils underwent a 10-min bilateral common carotid artery occlusion. HU-211, administered iv at 4 mg/kg, 30 min postischemia, induced statistically significant neuroprotection of the CA1 subfield of the hippocampus. A dose-response study demonstrated an inverted Ucurve in which the 4 mg/kg dose induced the best neuroprotection in the CA1 subfield of the hippocampus (p < 0.05 ANOVA followed by Duncan's post-hoc test). The therapeutic window was then investigated, and inanother study, HU-211 4 mg/kg were administered iv at 30, 60, 120, and 180 min postinsult. A statistically significant neuroprotection was detected at 30 and 60 min administration postinsult.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:40:54