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Titolo:
VAGAL-INDUCED TACHYCARDIA - RELEASE OF VASOACTIVE-INTESTINAL-PEPTIDE AND PEPTIDE HI
Autore:
ANDERSON FL; KRALIOS AC; CLUFF N; HANSON GR;
Indirizzi:
UNIV UTAH HOSP,DIV CARDIOL,50 N MED DR SALT LAKE CITY UT 84132 UNIV UTAH,SCH MED,DEPT INTERNAL MED CARDIOL SALT LAKE CITY UT 84132 UNIV UTAH,SCH MED,DEPT PHARMACOL SALT LAKE CITY UT 84132 VET AFFAIRS MED CTR SALT LAKE CITY UT 84132
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 36, anno: 1994,
pagine: 2019 - 2024
SICI:
0363-6135(1994)36:5<2019:VT-ROV>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL-TRACT; CANINE HEARTS; CO-EXISTENCE; BLOOD-FLOW; VIP; PHI; POLYPEPTIDE; NERVES; DOGS; NPY;
Keywords:
VAGAL STIMULATION; CARDIAC LYMPH; CORONARY SINUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
F.L. Anderson et al., "VAGAL-INDUCED TACHYCARDIA - RELEASE OF VASOACTIVE-INTESTINAL-PEPTIDE AND PEPTIDE HI", American journal of physiology. Heart and circulatory physiology, 36(5), 1994, pp. 2019-2024

Abstract

The relationship between vagal-induced tachycardia (VT) and release of vasoactive intestinal peptide (VIP) and peptide HI (PHI) into cardiac lymph and coronary sinus blood was studied in 23 alpha-chloralose-anesthetized open-chest dogs that were autonomically decentralized and pretreated with atropine and propranolol. After simultaneous right and left cervical vagal stimulation at 5 V, 20 Hz for 3 min mean +/- SE, increase in heart rate was 38 +/- 6 beats/min, and increase in lymph VIP output from control was 0.308 +/- 0.093 pg/min (P = 0.004). The decrease in VIP arterial minus coronary sinus concentration was not significant. The increase in heart rate did not significantly correlate withincrease in lymph VIP output (R(2) = 0.141) or decrease in VIP arterial minus coronary sinus concentration (R(2) = 0.059). The increases inheart rate and lymph VIP output were blocked by hexamethonium. Increase in lymph PHI output from control during VT (5 dogs) was 0.797 +/- 0.658 pg/min. Arterial-coronary sinus PHI concentration difference did not change in these dogs. These data indicate that VT is associated but not significantly correlated with VIP and PHI release into cardiac lymph. Cholinoceptive nicotinic receptors may mediate VIP release and VT in anesthetized dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:48:38