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Titolo:
DIFFERENT EFFECTS OF GRADUAL VS ACUTE ADENINE-NUCLEOTIDE DEPLETION ONATP COST OF MUSCLE-CONTRACTION
Autore:
FOLEY JM; ADAMS GR; MEYER RA;
Indirizzi:
MICHIGAN STATE UNIV,DEPT PHYS EDUC & EXERCISE SCI,RM 3,IM SPORTS CIRCLE E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT PHYSIOL E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT RADIOL E LANSING MI 48824
Titolo Testata:
American journal of physiology. Cell physiology
fascicolo: 5, volume: 36, anno: 1994,
pagine: 1177 - 1184
SICI:
0363-6143(1994)36:5<1177:DEOGVA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GUANIDINOPROPIONIC ACID; RAT SKELETAL-MUSCLE; GATED P-31 NMR; ISOMETRIC CONTRACTIONS; CREATINE-KINASE; ENERGY-COST; PH CHANGES; FIBERS; PHOSPHOCREATINE; TWITCH;
Keywords:
CREATINE DEPLETION; GUANIDINOPROPIONATE; RAT MUSCLE; MYOSIN ISOFORMS; PHOSPHOCREATINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Foley et al., "DIFFERENT EFFECTS OF GRADUAL VS ACUTE ADENINE-NUCLEOTIDE DEPLETION ONATP COST OF MUSCLE-CONTRACTION", American journal of physiology. Cell physiology, 36(5), 1994, pp. 1177-1184

Abstract

ATP and phosphocreatine (PCr) levels were chronically reduced in rat fast-twitch muscle by 40 and 87%, respectively, after rats were fed a diet containing 1% beta-guanidinopropionate (beta-GPA) for 9 wk. Myosin heavy chain distribution of superficial gastrocnemius muscle changedfrom 22:78% type IIA/type IIB in control to 39:61% in GPA-treated muscles. ATP cost of contractions was estimated from the PCr changes measured by gated P-31-nuclear magnetic resonance after brief (<6 s) bursts of contractions. There was no significant change in the ATP cost of either twitch (0.3 mu mol.g(-1).twitch(-1)) or tetanic (2.5 mu mol.g(-1).100 ms tetanus(-1)) contractions in gastrocnemius muscle after chronic phosphagen depletion due to beta-GPA feeding. In two other groups of rats, ATP of gastrocnemius muscles was acutely depleted to inosine 5'-monophosphate (IMP) by tetanic stimulation. IMP reamination was inhibited during a subsequent 75-min recovery period in one group by hadacidin treatment (100 mg/kg), resulting in 46% ATP depletion compared with the similarly stimulated and recovered control group. In contrast to gradual ATP depletion due to beta-GPA feeding, this acute ATP depletion treatment was associated with a 39% decrease in ATP cost of twitch contractions.

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Documento generato il 03/12/20 alle ore 12:19:32