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Titolo:
ATRIAL-NATRIURETIC-PEPTIDE RECEPTORS ARE PRESENT AND FUNCTIONAL BY MIDGESTATION IN FETAL SHEEP
Autore:
FRAENKEL MB; POTOCNIK SJ; WINTOUR EM;
Indirizzi:
UNIV MELBOURNE,HOWARD FLOREY INST EXPTL PHYSIOL & MED PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,HOWARD FLOREY INST EXPTL PHYSIOL & MED PARKVILLE VIC 3052 AUSTRALIA
Titolo Testata:
American journal of physiology. Renal, fluid and electrolyte physiology
fascicolo: 5, volume: 36, anno: 1994,
pagine: 825 - 830
SICI:
0363-6127(1994)36:5<825:ARAPAF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; GUANYLATE-CYCLASE; ENDOTHELIAL-CELLS; PORCINE BRAIN; OVINE FETAL; HOMEOSTASIS; MATURATION; ACTIVATION; PREMATURE; SEQUENCE;
Keywords:
OVINE FETUS; KIDNEY; ATRIAL NATRIURETIC PEPTIDE RECEPTOR MESSENGER RIBONUCLEIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Fraenkel et al., "ATRIAL-NATRIURETIC-PEPTIDE RECEPTORS ARE PRESENT AND FUNCTIONAL BY MIDGESTATION IN FETAL SHEEP", American journal of physiology. Renal, fluid and electrolyte physiology, 36(5), 1994, pp. 825-830

Abstract

This study examined the ontogeny of the mRNA for three atrial natriuretic peptide (ANP) receptors in the ovine fetal kidney and the effect of systemic ANP infusion in the very immature ovine fetus. mRNA was isolated from the kidneys of 60-, 100-, and 140-day fetuses (n = 4 at each age). Northern blots [5 mu g poly(A)(+) RNA per track] were probed for the guanylate cyclase (GC)-A, GC-B, and clearance receptors, usingp-actin as a control for variations in loading. The results were quantitated using laser densitometry. Levels of clearance receptor mRNA were significantly higher in 140-day than 60-day fetal kidneys (P < 0.05), whereas levels of mRNA for the GC-A and GC-B receptors remained steady. We propose that binding of ANP to an increased number of C receptors in the late-gestation fetal kidney could explain the previously documented increase in total ANP receptor number in late-gestation ovinekidneys without increased ANP biological activity. Systemic ANP infusion into four fetuses of = 74 days gestation resulted in a natriuresisand diuresis, indicating the presence of functional ANP receptors in the ovine kidney early in gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:39:51