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Titolo:
IMMUNOGENIC COMBINATIONS OF HIV-1 B-EPITOPES AND HETEROLOGOUS T-CELL-EPITOPES
Autore:
ISAGULIANTS M; RUDEN U; GILLJAM G; WAHREN B;
Indirizzi:
SWEDISH INST INFECT DIS CONTROL,DEPT VIROL S-10521 STOCKHOLM SWEDEN DI IVANOVSKII INST VIROL MOSCOW 123098 RUSSIA KAROLINSKA INST,DEPT MICROBIOL & TUMOR BIOL S-10521 STOCKHOLM SWEDEN
Titolo Testata:
Immunology letters
fascicolo: 3, volume: 42, anno: 1994,
pagine: 173 - 178
SICI:
0165-2478(1994)42:3<173:ICOHBA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM; SYNTHETIC PEPTIDE; CIRCUMSPOROZOITE PROTEIN; ENVELOPE GLYCOPROTEINS; VACCINE DEVELOPMENT; CORE PARTICLES; CLASS-II; RECOGNITION; DETERMINANTS; ANTIBODY;
Keywords:
ANTI-HIV-1 IMMUNE RESPONSE; B + T-CELL EPITOPE COMPOSITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Isaguliants et al., "IMMUNOGENIC COMBINATIONS OF HIV-1 B-EPITOPES AND HETEROLOGOUS T-CELL-EPITOPES", Immunology letters, 42(3), 1994, pp. 173-178

Abstract

Peptides were synthesized which combined HIV-1 B-epitopes from gp41, p34pol and heterologous T-cell epitopes from hepatitis B virus (HBV) core or tetanus toroid. Mixtures of these composite peptides and peptides representing single HIV-1 B-epitopes were used to immunize rabbits in an adjuvant-free immunization regimen. Fusion to T-cell epitopes made the HIV-1 B-epitopes immunogenic and high titers of anti-HIV-1 antibodies were reached. Efficient antibody response against an immunorecessive HIV-1 B-epitope from p34pol introduced as a B + T-composite alsodeveloped in rabbits pre-immunized by composites of the same T-cell epitopes but with a B-epitope from gp41. Fusion changed the fine antigenicity of the epitopes, but at least part of the antibodies against gp41-containing B + T composites recognized whole viral gp160. Compositepeptides stimulated T-cells in the majority of the immunized animals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 14:25:09