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Titolo:
L3T4(-HELPER CELLS ARE REQUIRED FOR IN-VITRO MATURATION OF IN-VIVO PRIMED T-CELLS IN THE CYTOTOXIC RESPONSE TO MHC CLASS-I DISPARATE CELLS FOLLOWING FOOTPAD IMMUNIZATION() BUT NOT LYT2(+) T)
Autore:
AZHIPA OY; BRONDZ BD;
Indirizzi:
RUSSIAN ACAD MED SCI,CANC RES CTR,INST CARCINOGENESIS,IMMUN REGULAT MECHANISMS LAB MOSCOW 115478 RUSSIA
Titolo Testata:
Immunology letters
fascicolo: 3, volume: 42, anno: 1994,
pagine: 117 - 122
SICI:
0165-2478(1994)42:3<117:LCARFI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATORY FACTOR-I; LYMPHOCYTES-T; MONOCLONAL-ANTIBODY; REACTIVE LYT-2+; INVIVO; INTERLEUKIN-2; ANTIGENS; SUBSETS; DIFFERENTIATION; ALLOANTIGENS;
Keywords:
CYTOTOXIC T LYMPHOCYTE; CLASS I MHC ALLOANTIGEN; ANTIGEN PRESENTATION PATHWAY; ANTIGEN ADMINISTRATION ROUTE; FOOTPAD IMMUNIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
O.Y. Azhipa e B.D. Brondz, "L3T4(-HELPER CELLS ARE REQUIRED FOR IN-VITRO MATURATION OF IN-VIVO PRIMED T-CELLS IN THE CYTOTOXIC RESPONSE TO MHC CLASS-I DISPARATE CELLS FOLLOWING FOOTPAD IMMUNIZATION() BUT NOT LYT2(+) T)", Immunology letters, 42(3), 1994, pp. 117-122

Abstract

The induction characteristics of major histocompatibility complex (MHC) class I-specific cytotoxic T lymphocytes (CTL) after footpad immunization were studied. Primary CTL were generated in the regional lymph nodes of C57Bl/6 mice by footpad injection with 10(7) irradiated (2000rad) spleen cells from MHC class I mutant mouse strain (bm1) followedby a short in vitro culturing without antigen. The requirement of accessory cells and L3T4(+) T cells during in vitro maturation of in vivoprimed CTL precursor (CTL(p)) was shown. Moreover, using inhibitory antibodies, the need for IL-2 and IL-4 for in vitro maturation of CTL was established. We have suggested that accessory cells act at the level of L3T4(+) T cells which in turn non-specifically up-regulate the CTL response through the production of growth and differentiation factors. Thus, the T-helper population of L3T4(+) but not Lyt2(+) phenotype appears to be recruited in the in vitro maturation of in vivo primed CTL(p) in a given system. Possible mechanisms of this phenomenon are discussed.

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Documento generato il 14/07/20 alle ore 05:13:37