Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TASK-DEPENDENT EFFECTS OF INTRAAMYGDALA MORPHINE INJECTIONS - ATTENUATION BY INTRAAMYGDALA GLUCOSE INJECTIONS
Autore:
RAGOZZINO ME; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
The Journal of neuroscience
fascicolo: 12, volume: 14, anno: 1994,
pagine: 7478 - 7485
SICI:
0270-6474(1994)14:12<7478:TEOIMI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION PERFORMANCE; MEDIAL SEPTAL AREA; WORKING MEMORY; ACETYLCHOLINE SYNTHESIS; LOCOMOTOR-ACTIVITY; SPATIAL-MEMORY; ELDERLY HUMANS; RAT AMYGDALA; LESIONS; MICE;
Keywords:
MEMORY; GLUCOSE; MORPHINE; AMYGDALA; INHIBITORY AVOIDANCE; SPONTANEOUS ALTERNATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Ragozzino e P.E. Gold, "TASK-DEPENDENT EFFECTS OF INTRAAMYGDALA MORPHINE INJECTIONS - ATTENUATION BY INTRAAMYGDALA GLUCOSE INJECTIONS", The Journal of neuroscience, 14(12), 1994, pp. 7478-7485

Abstract

Intraseptal injections of morphine impair learning and memory in rats, and these impairments are reversed by intraseptal injections of glucose. With evidence that injections of morphine into the amygdala also impair memory for some tasks, the present experiment determined whether (1) intra-amygdala morphine injections impair performance in inhibitory avoidance and spontaneous alternation tasks, and (2) intra-amygdala glucose injections attenuate the effects of intra-amygdala morphine injections. Rats receiving bilateral injections of morphine (4.0 nmol)into the amygdala, 30 min prior to training in inhibitory avoidance, had retention latencies significantly lower than those of unoperated and CSF controls when tested 24 hr later. Bilateral morphine injections(4.0 or 8.0 nmol) 30 min prior to testing in a spontaneous alternation task did not alter performance. The morphine-induced impairment observed in inhibitory avoidance was not due to diffusion up the cannulas,altered sensitivity to shock, or seizure activity. A glucose dose of 16.67 nmol, but not 8.33 nmol, injected into the amygdala attenuated the morphine-induced deficit in inhibitory avoidance. Rats receiving CSF into the amygdala exhibited decreased retention latencies in inhibitory avoidance compared to those of unoperated controls. This decrease was not attenuated by glucose at doses of 8.33 and 16.67 nmol. Therefore, these findings suggest that the amygdala is another brain region in which glucose affects brain functions, possibly by interacting with the opioid system and/or other neurotransmitter systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:44:34