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Titolo:
CONTRACTION-EXCITATION FEEDBACK IN ATRIAL REENTRY - ROLE OF VELOCITY OF MECHANICAL STRETCH
Autore:
YAMASHITA T; OIKAWA N; MURAKAWA Y; NAKAJIMA T; OMATA M; INOUE H;
Indirizzi:
UNIV TOKYO,FAC MED,DEPT INTERNAL MED 2,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN TOYAMA MED & PHARMACEUT UNIV,DEPT INTERNAL MED 2 TOYAMA 93001 JAPAN
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 4, volume: 36, anno: 1994,
pagine: 80001254 - 80001262
SICI:
0363-6135(1994)36:4<80001254:CFIAR->2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MECHANOELECTRICAL FEEDBACK; INDUCED ARRHYTHMIAS; ACTION-POTENTIALS; ION CHANNELS; REFRACTORINESS; REPOLARIZATION; GADOLINIUM; VENTRICLES; AFTERLOAD; RELEVANCE;
Keywords:
VARIATIONS IN CYCLE LENGTH; STRETCH; REFRACTORINESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T. Yamashita et al., "CONTRACTION-EXCITATION FEEDBACK IN ATRIAL REENTRY - ROLE OF VELOCITY OF MECHANICAL STRETCH", American journal of physiology. Heart and circulatory physiology, 36(4), 1994, pp. 80001254-80001262

Abstract

To determine the effects of atrial stretch on atrial flutter, we analyzed variations in atrial flutter cycle length (CL) caused by ventricular contraction in five dogs with artificially induced atrioventricular Mock. In contrast to absence of variations in CL during sustained ventricular asystole, atrial stretch by ventricular contraction consistently produced phasic variations in CL. The variations were not confined to any specific atrial sites, but depended on the time of ventricular contraction relative to atrial activation phase. The phase-response curve of the variations was closely related to that of the velocity ofchanges in the atrial pressure with no time lags, but not to that of the atrial pressure itself. Pharmacological denervation did not abolish the variations. Conventional electrophysiological study revealed greater changes in intra-atrial activation time by atrial stretch at a short pacing cycle length than at a longer one, suggestive of changes inrepolarization by mechanical stretch. In conclusion, atrial stretch caused by ventricular contraction produces phasic variations in CL, theextent of which depends on the velocity of the mechanical stretch of atrial muscles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:58:45