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Titolo:
PHARMACOKINETICS AND BIOAVAILABILITY OF BENPERIDOL IN SCHIZOPHRENIC-PATIENTS AFTER INTRAVENOUS AND 2 DIFFERENT KINDS OF ORAL APPLICATION
Autore:
SEILER W; WETZEL H; HILLERT A; SCHOLLNHAMMER G; LANGER M; BARLAGE U; HIEMKE C;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55101 MAINZ GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55101 MAINZ GERMANY TROPONWERKE GMBH & CO KG,DEPT CLIN RES D-51063 COLOGNE GERMANY
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 116, anno: 1994,
pagine: 457 - 463
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALOPERIDOL PLASMA-LEVELS; REDUCED HALOPERIDOL;
Keywords:
NEUROLEPTIC; BENPERIDOL; REDUCED BENPERIDOL; PHARMACOKINETICS; BIOAVAILABILITY; SCHIZOPHRENICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
W. Seiler et al., "PHARMACOKINETICS AND BIOAVAILABILITY OF BENPERIDOL IN SCHIZOPHRENIC-PATIENTS AFTER INTRAVENOUS AND 2 DIFFERENT KINDS OF ORAL APPLICATION", Psychopharmacology, 116(4), 1994, pp. 457-463

Abstract

Pharmacokinetics and bioavailability of benperidol were determined in13 schizophrenic patients after acute administration of 6 mg benperidol as an intravenous (i.v.) bolus injection, orally as liquid, and orally as tablets using a partially randomized cross-over design. Drug plasma levels were determined by high performance liquid chromatography with electrochemical detection and subjected to model independent pharmacokinetic analyses. After i.v. dosing the geometric means (mean-g) were 3.2 min for the distribution half-life, 5.80 h for the eliminationhalf-life (t(1/2 beta)), 4.21 1/kg for the distribution volume, 7.50 h for the mean residence time (MRT), and 0.50 1/(h()kg) for the clearance. After oral administration as liquid and as tablet mean-g data for the time lag until the first appearance of measurable plasma concentrations were 0.33 and 1.1 h, mean-g t(1/2 beta) values were 5.5 and 4.7 h, respectively, mean-g t(max) data were 1.0 h and 2.7 h, mean-g MRTvalues were 8.44 and 8.84 h, and mean-g C-max (max)values were 10.2 and 7.3 ng/ml. Differences between liquid and tablet administration were statistically significant for time lag, t(max), and C-max. Mean-g absolute bioavailabilities were computed as 48.6% after liquid and 40.2%after tablet administration respectively. All parameters studied exhibited large intersubject variation. The plasma concentrations of the presumed metabolite ''reduced benperidol'' were found to be very low.

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Documento generato il 22/01/20 alle ore 18:38:48