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Titolo:
UNILATERAL NEONATAL INTRACEREBROVENTRICULAR 6-HYDROXYDOPAMINE ADMINISTRATION IN RATS .1. EFFECTS ON SPONTANEOUS AND DRUG-INDUCED ROTATIONALBEHAVIOR AND ON POSTMORTEM MONOAMINE LEVELS
Autore:
LUTHMAN J; HERRERAMARSCHITZ M; LINDQVIST E;
Indirizzi:
KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL STOCKHOLM SWEDEN KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL STOCKHOLM SWEDEN KAROLINSKA INST,DEPT NEUROSCI STOCKHOLM SWEDEN ASTRA ARCUS AB,CNS,PRECLIN RES & DEV,DEPT NEUROPHARMACOL SODERTALJE SWEDEN
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 116, anno: 1994,
pagine: 443 - 450
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; DEPLETING BRAIN-LESIONS; INTRACEREBRAL DIALYSIS; PARA-CHLOROAMPHETAMINE; DOPAMINE-RECEPTORS; 6-OHDA LESIONS; APOMORPHINE; AMPHETAMINE; HYPERACTIVITY; PERGOLIDE;
Keywords:
6-HYDROXYDOPAMINE; NEONATAL LESION; ROTATIONAL BEHAVIOR; D-AMPHETAMINE; APOMORPHINE; P-CHLOROAMPHETAMINE; CAFFEINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
J. Luthman et al., "UNILATERAL NEONATAL INTRACEREBROVENTRICULAR 6-HYDROXYDOPAMINE ADMINISTRATION IN RATS .1. EFFECTS ON SPONTANEOUS AND DRUG-INDUCED ROTATIONALBEHAVIOR AND ON POSTMORTEM MONOAMINE LEVELS", Psychopharmacology, 116(4), 1994, pp. 443-450

Abstract

6-Hydroxydopamine (6-OHDA; 100 mu g in 5 mu l22222) was injected intothe right ventricle (intracerebroventricular, ICV) of 3-day old Sprague-DawIey rats in an attempt to produce a unilateral neonataI dopamine(DA) lesion. At adult stage, the rats were studied for spontaneous, handling- and drug-induced rotational behaviour. The 6-OHDA-treated rats showed hyperreactivity at handling, in the animal facility and in the experimental sets. This behaviour was not observed in vehicle-treated rats, and it did not decrease through the successive experiments. Apomorphine (0.05-1 mg/kg, SC) and caffeine (20 mg/kg SC) produced contralateral rotation in neonatal 6-OHDA, but not in vehicle-injected rats. c-l-Amphetamine (0.2-2 mg/kg, SC) produced strong, dose-dependent, ipsilateral rotation, while the serotonin (5-HT) releasing agent, p-chloroamphetamine (2 mg/kg, SC) produced a short-lasting and weak ipsilateral rotation in the 6-OHDA-treated rats. On the 6-OHDA-injected side,DA and metabolites levels were reduced by >70-90% in the striatum, the nucleus accumbens and the tubercuIum olfactorium, while in the mesencephalon a 50% decrease was found. On the contralateral side, restricted decreases in DA and metabolites were observed. Noradrenaline (NA) levels were decreased bilaterally in the forebrain. In contrast, 5-HT and 5-hydroxyindoIeacetic acid (5-HIAA) levels were increased in the ipsilateral striatum (>180%), and tuberculum olfactorium (>120%). Thus, neonatal unilateral ICV 6-OHDA administration produced a significant unilateral decrease in tissue levels of DA and metabolites, which was most marked in the striatum. Changes in NA and 5-HT levels were also found in telencephalic and mesencephalic regions. The 6-OHDA lesion led to a lasting handling-related hyperreactivity and, following stimulation with direct or indirect DA agonists, to rotational behaviour with apattern similar to that observed in rats unilaterally lesioned at adult stage with 6-OHDA.

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Documento generato il 22/01/20 alle ore 12:31:39