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Titolo:
SYNERGISTIC EFFECT OF RHTNF-ALPHA AND RHIL-1-ALPHA IN INDUCING ANOREXIA IN RATS
Autore:
YANG ZJ; KOSEKI M; MEGUID MM; GLEASON JR; DEBONIS D;
Indirizzi:
SUNY SYRACUSE,UNIV HOSP,CTR HLTH SCI,DEPT SURG,SURG METAB & NUTR LAB,750 E ADAMS ST SYRACUSE NY 13210 SUNY SYRACUSE,UNIV HOSP,CTR HLTH SCI,DEPT SURG,SURG METAB & NUTR LAB SYRACUSE NY 13210 SYRACUSE UNIV,COLL ARTS & SCI,STAT PROGRAM SYRACUSE NY 13244
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 36, anno: 1994,
pagine: 180001056 - 180001064
SICI:
0363-6119(1994)36:4<180001056:SEORAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR NECROSIS FACTOR; FOOD-INTAKE; INTERLEUKIN-1; BIOLOGY; RELEASE; CHOLECYSTOKININ; CACHECTIN/TNF; HYPOTHALAMUS; ENDOTOXIN; CACHEXIA;
Keywords:
CYTOKINE; INTERLEUKIN-1; TUMOR NECROSIS FACTOR; FEEDING; FOOD INTAKE; MEAL SIZE; MEAL NUMBER; MEAL SNIFFS; CHRONIC INFUSION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Z.J. Yang et al., "SYNERGISTIC EFFECT OF RHTNF-ALPHA AND RHIL-1-ALPHA IN INDUCING ANOREXIA IN RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 36(4), 1994, pp. 180001056-180001064

Abstract

To investigate whether there is a synergistic effect of recombinant human tumor necrosis factor-alpha (rhTNF-alpha) and recombinant human interleukin-1 alpha (rhIL-1 alpha) in inducing anorexia, 32 rats with jugular catheters were studied (8 rats/group): controls received normalsaline; the IL-1 group received rhIL-1 alpha (10 mu g/kg); the TNF group received rhTNF-alpha (30 mu g/kg); and the IL-1 + TNF group received the same concentration of both rhIL-1 alpha + rhTNF-alpha for 3 days; solutions were then switched to normal saline. No significant decrease in light- and dark-phase food intake occurred during infusion of subeffective rhTNF-alpha. Food intake was decreased on the first rhIL-1alpha infusion day because of a decreased meal number during the darkphase. A significant decrease in food intake occurred with combined infusion of rhIL-1 alpha + rhTNF-alpha because of a reduction in meal number during dark phase and meal size during light phase. Our results show that rhIL-1 alpha and rhTNF-alpha, when administered concurrently, had a synergistic effect in inducing anorexia, suggesting that low concentrations of these cytokines as produced endogenously may have potential effects on other biological functions in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:24:18