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Titolo:
CHRONIC NUCLEUS-TRACTUS-SOLITARIUS LESIONS DO NOT PREVENT HYPOVOLEMIA-INDUCED VASOPRESSIN SECRETION IN RATS
Autore:
SCHREIHOFER AM; STRICKER EM; SVED AF;
Indirizzi:
UNIV PITTSBURGH,DEPT NEUROSCI,446 CRAWFORD HALL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT NEUROSCI PITTSBURGH PA 15260
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 36, anno: 1994,
pagine: 180000965 - 180000973
SICI:
0363-6119(1994)36:4<180000965:CNLDNP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINOAORTIC-DENERVATED RATS; CONSCIOUS DOGS; BLOOD-PRESSURE; PLASMA VASOPRESSIN; VAGAL AFFERENTS; BARORECEPTOR DENERVATION; ARTERIAL BARORECEPTORS; CIRCULATORY CONTROL; CARDIAC RECEPTORS; ANGIOTENSIN-II;
Keywords:
HEMORRHAGE; POLYETHYLENE GLYCOL; ARTERIAL PRESSURE; HEART RATE; SINOAORTIC DENERVATION; BARORECEPTORS; VAGUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Schreihofer et al., "CHRONIC NUCLEUS-TRACTUS-SOLITARIUS LESIONS DO NOT PREVENT HYPOVOLEMIA-INDUCED VASOPRESSIN SECRETION IN RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 36(4), 1994, pp. 180000965-180000973

Abstract

The present study examined the hypothesis that hypovolemia stimulatesvasopressin (VP) secretion by removing tonic inhibitory baroreceptor input. Serial hemorrhage (4 samples of 2 ml/300 g body wt taken every 10 min) increased plasma VP levels in conscious rats devoid of cardiacand arterial baroreceptor reflex responses due to chronic bilateral lesions of nucleus tractus solitarius (NTS). The VP response to hemorrhage was similar to that seen in control rats and chronic sinoaortic-denervated (SAD) rats. After subcutaneous injection of 30% polyethylene glycol, NTS-lesioned rats, SAD rats, and control rats had elevated VP levels that correlated with the induced depletion of plasma volume. Additionally, in alpha-chloralose-anesthetized control rats, chronic SADrats, and chronic NTS-lesioned rats, bilateral vagotomy had minimal effects on basal VP levels, and vagotomy in chronic NTS-lesioned rats did not prevent hemorrhage-evoked increases in VP secretion. These results do not support the idea that hemorrhage-induced VP secretion occurs through reduction in tonic inhibitory baroreceptor input. Instead, neither cardiac nor arterial baroreceptor input appears to be necessaryfor hypovolemia-induced VP secretion in rats.

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Documento generato il 20/09/20 alle ore 19:57:53