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Titolo:
HEMODYNAMICS AND BAROREFLEX FUNCTION IN RATS WITH NEPHROTIC SYNDROME
Autore:
HINOJOSALABORDE C; JONES SY; DIBONA GF;
Indirizzi:
UNIV IOWA,COLL MED,DEPT INTERNAL MED IOWA CITY IA 52242 UNIV IOWA,COLL MED,DEPT INTERNAL MED IOWA CITY IA 52242 VET ADM MED CTR IOWA CITY IA 52242
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 4, volume: 36, anno: 1994,
pagine: 180000953 - 180000964
SICI:
0363-6119(1994)36:4<180000953:HABFIR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; HEART-FAILURE; SODIUM RETENTION; NERVE ACTIVITY; RENAL NERVES; REFLEX;
Keywords:
ARTERIAL BARORECEPTORS; CARDIAC VOLUME RECEPTORS; RENAL SYMPATHETIC NERVES; EDEMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C. Hinojosalaborde et al., "HEMODYNAMICS AND BAROREFLEX FUNCTION IN RATS WITH NEPHROTIC SYNDROME", American journal of physiology. Regulatory, integrative and comparative physiology, 36(4), 1994, pp. 180000953-180000964

Abstract

The excess renal sodium retention leading to edema formation in the nephrotic syndrome (NS) is substantially dependent on increased efferent renal sympathetic nerve activity (RSNA). This study examined whetherthe hypoalbuminemia in NS is reflected as a decrease in cardiac output or cardiac function and whether the increased RSNA in NS is due to alterations in arterial and/or cardiopulmonary baroreflex function, NS was induced in rats with adriamycin (3.5 mg/kg iv), and they were studied 4 wk after injection. Mean arterial pressure (MAP) was similar in control (C) and NS rats. Cardiac indexes (CIs; cardiac output/body wt)were 29 +/- 1 and 26 +/- 1 ml.min(-1).100 g(-1) in C and NS rats, respectively. Total peripheral resistance indexes were significantly greater in NS than in C rats (4.7 +/- 0.2 vs. 4.1 +/- 0.1 mmHg.100 g.min ml(-1)). Cardiac function during increases in cardiac filling pressure was not different between C and NS rats. The afferent limb of the arterial baroreflex was assessed by measuring aortic depressor nerve activity (ADNA) while the efferent limb was assessed by measuring RSNA in Cand NS rats during increases in MAP. The central component of the arterial baroreflex was assessed from plots of RSNA (output) vs. ADNA (input). Comparisons between C and NS rats before and after vagotomy revealed no differences in the gains of any component of the arterial baroreflex. The cardiopulmonary baroreflex was assessed in a similar manner by measuring afferent vagus nerve activity (VGNA) and efferent RSNA during volume expansion before and after sinoaortic denervation (SAD). Before SAD, gains were similar in C and NS rats. After SAD, gains of the total (-1.59 +/- 0.44 vs. -3.64 +/- 0.65 %/mmHg) and the central/ efferent limb (-0.26 +/- 0.07 vs. -0,67 +/- 0.14 %/%) were significantly reduced (P < 0.05) in NS compared with C rats while the gain of theafferent limb of the reflex was similar in C and NS rats. These results indicate that NS rats with significant hypoalbuminemia maintain an arterial pressure similar to C rats by increasing total peripheral resistance, which serves to offset the tendency to a lower CI. Arterial baroreflex function in NS does not differ from that in C, but decreasedcardiopulmonary baroreflex inhibition of RSNA in NS may contribute tothe increased RSNA.

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Documento generato il 24/11/20 alle ore 22:29:43