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Titolo:
BOTH UVA AND UVB INDUCE CYTOSKELETON-DEPENDENT SURFACE BLEBBING IN EPIDERMOID CELLS
Autore:
MALORNI W; DONELLI G; STRAFACE E; SANTINI MT; PARADISI S; GIACOMONI PU;
Indirizzi:
IST SUPER SANITA,DEPT ULTRASTRUCT,VIALE REGINA ELENA 299 I-00161 ROMEITALY LOREAL,CTR RECH CHARLES ZVIAK F-92583 CLICHY FRANCE
Titolo Testata:
Journal of photochemistry and photobiology.B, Biology
fascicolo: 3, volume: 26, anno: 1994,
pagine: 265 - 270
SICI:
1011-1344(1994)26:3<265:BUAUIC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
KERATIN INTERMEDIATE FILAMENTS; HUMAN-SKIN FIBROBLASTS; ULTRAVIOLET-RADIATION; MOUSE EPIDERMIS; SUNBURN CELL; IRRADIATION; DAMAGE; OXYGEN; DNA; STRESS;
Keywords:
UVA; UVB; CYTOSKELETON-DEPENDENT SURFACE BLEBBING; EPIDERMOID CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
W. Malorni et al., "BOTH UVA AND UVB INDUCE CYTOSKELETON-DEPENDENT SURFACE BLEBBING IN EPIDERMOID CELLS", Journal of photochemistry and photobiology.B, Biology, 26(3), 1994, pp. 265-270

Abstract

Data on the morphological changes induced by UVA or UVB irradiation of A431 epidermoid cells in culture are presented. After irradiation with different doses of UVB (120-2400 J m(-2)) or UVA (10(4)-10(5) J m(-2)), the membrane and cytoskeleton of these cells were analysed by immunofluorescence and scanning electron microscopy at different times after exposure (0-48 h). Both UVA and UVB alter microtubules and microfilaments and surface blebs are formed after UV irradiation. In particular, UVB induces multiple small blebs on the cells, while UVA induces one single large bleb on each cell. Since cytoskeletal damage and surface blebbing of this type are also induced by oxidative stress, these results add to the body of evidence indicating that UV radiation is capable of pro-oxidant behaviour. Specifically, the morphological changesdescribed in this paper are reminiscent of the modifications which accompany epidermal keratinocytes during their transformation to sunburncells after UV irradiation. The physiological implications of these findings are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:44:28