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Titolo:
PLATELET ACTIVATION IN MAJOR SURGICAL STRESS - INFLUENCE OF COMBINED EPIDURAL AND GENERAL-ANESTHESIA
Autore:
NAESH O; HINDBERG I; FRIIS J; CHRISTIANSEN C; PEDERSEN T; TRAPJENSEN J; LUND JO;
Indirizzi:
MOLNDALS SJUKHUS,DEPT ANAESTHESIA & INTENS CARE S-43180 MOLNDAL SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT ANAESTHESIA & INTENS CARE S-41345GOTHENBURG SWEDEN FREDERIKSBERG UNIV HOSP,DEPT CLIN CHEM COPENHAGEN DENMARK FREDERIKSBERG UNIV HOSP,DEPT SURG GASTROENTEROL COPENHAGEN DENMARK FREDERIKSBERG UNIV HOSP,DEPT ANAESTHESIA COPENHAGEN DENMARK FREDERIKSBERG UNIV HOSP,DEPT CLIN PHYSIOL COPENHAGEN DENMARK
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 8, volume: 38, anno: 1994,
pagine: 820 - 825
SICI:
0001-5172(1994)38:8<820:PAIMSS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER ABDOMINAL-SURGERY; RELEASE REACTION; MENTAL STRESS; INVIVO; PLASMA; AGGREGABILITY; AGGREGATION; INVITRO; CATECHOLAMINES; THROMBOXANE;
Keywords:
PLATELETS; SURGERY; ANESTHESIA; STRESS RESPONSE; SEROTONIN; BETA-THROMBOGLOBULIN; THROMBOXANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
O. Naesh et al., "PLATELET ACTIVATION IN MAJOR SURGICAL STRESS - INFLUENCE OF COMBINED EPIDURAL AND GENERAL-ANESTHESIA", Acta anaesthesiologica Scandinavica, 38(8), 1994, pp. 820-825

Abstract

Platelets are activated in surgery releasing vasoactive substances such as serotonin and thromboxane. Platelets become temporarily hypoaggregable during surgery followed by a postoperative hyperaggregability. Local anaesthetics are known to inhibit platelet function but earlier reports are conflicting. In order to study the impact of the combined use of general and regional anaesthesia on platelet function during major surgery 16 otherwise healthy patients were randomised to either general anaesthesia (GA) (n=8) or GA combined with epidural anaesthesia (GA+EPI) (n=8) for elective upper abdominal surgery. Cyclic 3'5'-adenosine monophosphate, plasma glucose, plasma cortisol and the rate pressure product (RPP) were markers of the stress response. ADP-induced platelet aggregation and the release products beta-thromboglobulin, serotonin and thromboxane 2 were measured in plasma before and during as well as for 3 days after surgery. A marked stress response was noted in both groups and epidural anaesthesia (EPI) only reduced the rate pressure product (RPP). Platelet aggregation was reduced during surgery, a little more so in the GA+EPI group. Postoperatively both groups showedsignificant hyperaggregability. The release products were not significantly influenced by regional anaesthesia. In conclusion epidural as combined with general anaesthesia affects platelet responses to major abdominal surgery only to a minor extent, although it may attenuate thehaemodynamic response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:45:27