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Titolo:
CEREBRAL BLOOD-FLOW AND METABOLIC RESPONSES TO SUSTAINED HYPERCAPNIA IN AWAKE SHEEP
Autore:
YANG SP; KRASNEY JA;
Indirizzi:
SUNY BUFFALO,SCH MED & BIOMED SCI,DEPT PHYSIOL,HERMANN RAHN LAB EXPTLPHYSIOL,124 SHERMAN HALL BUFFALO NY 14214
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 1, volume: 15, anno: 1995,
pagine: 115 - 123
SICI:
0271-678X(1995)15:1<115:CBAMRT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONSCIOUS SHEEP; CIRCULATORY RESPONSES; HIGH-ALTITUDE; HYPOXIA; BRAIN;
Keywords:
BRAIN BICARBONATE; BRAIN EDEMA; BRAIN GLUCOSE METABOLISM; BRAIN LACTATE; BRAIN O-2 UPTAKE; CEREBRAL FLUID SHIFTS; CO2 RETENTION; HYPERVENTILATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Yang e J.A. Krasney, "CEREBRAL BLOOD-FLOW AND METABOLIC RESPONSES TO SUSTAINED HYPERCAPNIA IN AWAKE SHEEP", Journal of cerebral blood flow and metabolism, 15(1), 1995, pp. 115-123

Abstract

This investigation determined the effects of sustained hypercapnia oncerebral blood flow (CBF; radiolabeled microspheres), cerebral metabolic rates for O-2 and glucose (CMRO(2) and CMR(glc)), and brain water content in conscious sheep instrumented with aortic, left ventricular,vena cava, and brain sagittal sinus catheters. PaCO2 was elevated from 38 +/- 3 to 53 +/- 3 (mean +/- SD) mm Hg and PaO2 from 109 +/- 7 to 131 +/- 4 mm Hg for 96 h in an environmental chamber. Hypercapnia did not alter sheep behavior, food and water intake, arterial pressures, core temperature, or brain lactate release. Total and regional CBF and CBF/CMRO(2) reached peak values at 1 h and then readjusted, to stabilize at lower, but still elevated levels at 24 h and thereafter. CMRO(2)and CMR(glc) increased at 6 h and thereafter during hypercapnia. PaCO2, CBF, CMRO(2), and CMR(glc) remained elevated at 3 h after restoration to room air, while CBF/CMRO(2) returned to the control value. Frontal and occipital lobe wet-to-dry weight ratios increased modestly but significantly after hypercapnic exposure. It is concluded that sustained hypercapnia induces stable and nonadapting increases in both CBF and brain metabolism that persist for at least 3 h after restoration to room air in association with hypoventilization and modest elevations of brain water.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:25:11