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Titolo:
STRESS-INDUCED NOREPINEPHRINE RELEASE IN THE RAT PREFRONTAL CORTEX MEASURED BY MICRODIALYSIS
Autore:
NAKANE H; SHIMIZU N; HORI T;
Indirizzi:
KYUSHU UNIV 60,FAC MED,DEPT PHYSIOL FUKUOKA 812 JAPAN
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 6, volume: 36, anno: 1994,
pagine: 180001559 - 180001566
SICI:
0363-6119(1994)36:6<180001559:SNRITR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS; NORADRENERGIC FUNCTION; CATECHOLAMINE NEURONS; FRONTAL-CORTEX; ANXIETY; BRAIN; NORADRENALINE; INCREASES; DIAZEPAM; NUCLEUS;
Keywords:
IMMOBILIZATION STRESS; BENZODIAZEPINE; FG-7142;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
H. Nakane et al., "STRESS-INDUCED NOREPINEPHRINE RELEASE IN THE RAT PREFRONTAL CORTEX MEASURED BY MICRODIALYSIS", American journal of physiology. Regulatory, integrative and comparative physiology, 36(6), 1994, pp. 180001559-180001566

Abstract

Norepinephrine (NE) release in the medial prefrontal cortex (PFC) of rats was studied during immobilization using an intracerebral microdialysis technique. A series of experiments using pharmacological and physiological manipulations indicated that the NE recovered in the medialPFC dialysate was mainly derived from nerve terminals and that the dorsal noradrenergic bundle was a major source of NE in the medial PFC. Immobilization stress immediately elevated NE levels to 176.0 +/- 9.0%of basal release, and this increase continued for the entire period of stress and 20 min after termination of the stress. Preinjection of abenzodiazepine receptor agonist, diazepam (5 mg/kg ip), significantlyattenuated immobilization-induced NE release, while injection of an anxiogenic compound, FG-7142 (20 mg/kg ip), facilitated NE release in an obviously nonstressed condition. These results therefore suggest that stressful stimuli activate the NE system in the medial PFC, which may be modulated by an activation of benzodiazepine receptors in the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 20:25:56