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Titolo:
RENAL MEDULLARY CARCINOMA - THE 7TH SICKLE-CELL NEPHROPATHY
Autore:
DAVIS CJ; MOSTOFI FK; SESTERHENN IA;
Indirizzi:
ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL WASHINGTON DC 20306
Titolo Testata:
The American journal of surgical pathology
fascicolo: 1, volume: 19, anno: 1995,
pagine: 1 - 11
SICI:
0147-5185(1995)19:1<1:RMC-T7>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Keywords:
RENAL CARCINOMA; SICKLE CELL TRAIT; RENAL PELVIC CARCINOMA; COLLECTING DUCT CARCINOMA; HEMOGLOBIN S DISORDERS; RENAL MEDULLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Davis et al., "RENAL MEDULLARY CARCINOMA - THE 7TH SICKLE-CELL NEPHROPATHY", The American journal of surgical pathology, 19(1), 1995, pp. 1-11

Abstract

Over the last 22 years, we have encountered 34 examples of a highly aggressive neoplasm with a microscopic morphology that is highly predictive of finding sickled erythrocytes in the tissue. With the exceptionof one patient, all are believed to have had sickle cell trait or, inone case, hemoglobin SC disease. These 33 patients are the subject ofthis report and, where their race was known, they were all blacks between the ages of 11 and 39 years. Between the ages of 11 and 24 years,males predominated by 3 to 1. Beyond age 24, however, the tumors occurred equally in men and women. The dominant tumor mass was in the medulla and ranged from 4 to 12 cm in diameter. Mean size was 7 cm; median, 6 cm. Peripheral satellites in the renal cortex and pelvic soft tissues, as well as venous and lymphatic invasion, were usually present. The lesions exhibited a reticular, yolk sac-like, or adenoid cystic appearance, often with poorly differentiated areas in a highly desmoplastic stroma admired with neutrophils and usually marginated by lymphocytes. The tumors had usually metastasized when first discovered, and none was confined to the kidney at the time of nephrectomy. The mean duration of life after surgery was 15 weeks. These tumors probably arise in the calyceal epithelium in or near the renal papillae, the same sitethat produces the more familiar picture of unilateral hematuria in patients with sickle cell trait. We have concluded that renal medullary carcinoma represents another example of renal disease associated with sickle cell disorders. The other six are unilateral hematuria, papillary necrosis, nephrotic syndrome, renal infarction, inability to concentrate urine, and pyelonephritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 07:34:07