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Titolo:
THE INFLAMMATORY AND IMMUNE-RESPONSE TO MOUSEPOX (INFECTIOUS ECTROMELIA) VIRUS
Autore:
NIEMIALTOWSKI MG; DEFAUNDEZ IS; SKA MG; MALICKA E; TOKA FN; SCHOLLENBERGER A; POPIS A;
Indirizzi:
AGR UNIV WARSAW,FAC VET MED,DEPT MICROBIOL,GROCHOWSKA 272 PL-03849 WARSAW POLAND AGR UNIV WARSAW,FAC VET MED,DEPT PATHOL PL-03849 WARSAW POLAND
Titolo Testata:
Acta virologica
fascicolo: 5, volume: 38, anno: 1994,
pagine: 299 - 307
SICI:
0001-723X(1994)38:5<299:TIAITM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERALIZED VIRAL INFECTION; CD4+ T-CELLS; VACCINIA VIRUS; MYXOMA VIRUS; RESISTANCE; RECOVERY; MICE; MECHANISMS; PROTEIN; CD8+;
Keywords:
ECTROMELIA VIRUS; MOUSEPOX; INFLAMMATION; IMMUNE RESPONSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Niemialtowski et al., "THE INFLAMMATORY AND IMMUNE-RESPONSE TO MOUSEPOX (INFECTIOUS ECTROMELIA) VIRUS", Acta virologica, 38(5), 1994, pp. 299-307

Abstract

The ectromelia virus (EV) has been recognized as the etiological agent of a relatively common infection in laboratory mouse colonies aroundthe world, i.e., Europe (including Poland), USA and Asia. Due to widespread use of mice in biomedical research, it is important to study the biology of strains characteristic for a given country. This is particularly significant for the diagnosis, prevention and control ectromelia. In severe epizootics, approximately 90% morbidity is observed within colonies and mortality rate exceeding 70% is observed within 4 to 20 days from the appearance of clinical symptoms. The resistance to lethal infection is mouse strain-dependent. Several inbred strains of mice, including C57BL/6 and AKR are resistant to the lethal effects od EVinfection, while others, such as A and BALB/c are susceptible. Recentstudies indicate that (1) T lymphocytes, NK cells and interferon (IFN)-dependent host defenses must operate for the expression of resistance, (2) virus-specific T-cell precursors appear earlier in regional lymph nodes of resistant than susceptible mice, and (3) resistance mechanisms are expressed during early stages of infection. Over the past several years, (1) induction of anti-EV cytotoxic CD8(+) T lymhocytes (CTL) I responses in vivo in the absence of CD4(+) (T helper) cells, (2) importance of some cytokines e.g., IFN-gamma in EV clearance at all stages of infection, and (3) induction of nitric oxide (NO) synthase, which is necessary for a substantial antiviral activity of IFN-gamma, have been demonstrated. The effector mechanisms by which EV-specific immune cells (T lymphocytes) execute their protective and inflammatory functions are thought to involve the release of soluble mediators that attract, focus and activate cells at the infected sites. It is possiblethat the skin is the most relevant organ for studying the biology of an EV infection in vivo, yet very little is known concerning EV replication there and the importance of the skin's innate and immune response for recovery from viral infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:19:26