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Titolo:
FLOW-CYTOMETRY ANALYSIS OF PITUITARY-ADENOMAS
Autore:
FORNAS O; MATO ME; VIADER M; OLIVER B; TRESSERRES P; BARTUMEUS F; TUGUES D; PETRIZ J; MATIASGUIU X; WEBB SM;
Indirizzi:
AUTONOMOUS UNIV BARCELONA,HOSP SANTA CREU & ST PAU,SERV ENDOCRINOL,DEPT ENDOCRINOL E-08025 BARCELONA SPAIN AUTONOMOUS UNIV BARCELONA,HOSP SANTA CREU & ST PAU,DEPT NEUROSURG E-08025 BARCELONA SPAIN AUTONOMOUS UNIV BARCELONA,HOSP SANTA CREU & ST PAU,DEPT PATHOL E-08025 BARCELONA SPAIN HOSP DURAN & REYNALS,FLOW CYTOMETRY LAB,INST RECERCA ONCOL BARCELONA SPAIN AUTONOMOUS UNIV BARCELONA,HOSP SANTA CREU & ST PAU,SERV ENDOCRINOL,DEPT ENDOCRINOL E-08025 BARCELONA SPAIN
Titolo Testata:
Hormone research
fascicolo: 6, volume: 46, anno: 1996,
pagine: 257 - 262
SICI:
0301-0163(1996)46:6<257:FAOP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA CONTENT; CLINICAL BEHAVIOR; NUCLEAR ANTIGEN; TUMORS; PLOIDY; AUTOPSY; PHASE; P53;
Keywords:
PITUITARY ADENOMAS; TREATMENT; PROGNOSIS; CELL PROLIFERATION; FLOW CYTOMETRY; PLOIDY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
O. Fornas et al., "FLOW-CYTOMETRY ANALYSIS OF PITUITARY-ADENOMAS", Hormone research, 46(6), 1996, pp. 257-262

Abstract

Using flow cytometry, DNA content and index, and/or proliferative capacity (measuring proliferating cell nuclear antigen PCNA) in operated pituitary tumors, control pituitaries obtained at necropsy, and experimental pituitary hyperplasia induced in rats were analyzed. Simultaneous measurement of cell ploidy and proliferation differentiated normal pituitary (diploid DNA index and negative PCNA) from pituitary hyperplasia (diploid DNA index with intensely positive PCNA, between 30 and 72% of cells). In the tumors 83% (19/ 23) were positive for PCNA (between 3 and 84%) and 73% (17/23) aneuploid; only 1 tumor was diploid and negative for PCNA. Conclusions: Differentiation between normal and abnormal (neoplastic or hyperplastic) pituitary is possible by flow cytometry, but in the adenomas no correlation with postoperative clinical outcome was observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:57:17