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Titolo:
BEHAVIORAL EVIDENCE FOR THE EXISTENCE OF 2 POOLS OF CELLULAR INOSITOL
Autore:
BERSUDSKY Y; KAPLAN Z; SHAPIRO Y; AGAM G; KOFMAN O; BELMAKER RH;
Indirizzi:
MINIST HLTH,CTR MENTAL HLTH,IDA & SOLOMON STERN PSYCHIAT RES UNIT,POB4600 BEER SHEVA ISRAEL MINIST HLTH,CTR MENTAL HLTH,IDA & SOLOMON STERN PSYCHIAT RES UNIT BEER SHEVA ISRAEL SOROKA MED CTR,BIOCHEM LAB BEER SHEVA ISRAEL BEN GURION UNIV NEGEV,FAC HLTH SCI BEER SHEVA ISRAEL BEN GURION UNIV NEGEV,DEPT BEHAV SCI BEER SHEVA ISRAEL
Titolo Testata:
European neuropsychopharmacology
fascicolo: 4, volume: 4, anno: 1994,
pagine: 463 - 467
SICI:
0924-977X(1994)4:4<463:BEFTEO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LITHIUM-TREATED RATS; PHOSPHOINOSITIDE METABOLISM; BRAIN; MYOINOSITOL; SEIZURES; INCREASES;
Keywords:
INOSITOL; BEHAVIOR; LITHIUM PILOCARPINE SEIZURES; HYPERNATREMIA; HYPONATREMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
Y. Bersudsky et al., "BEHAVIORAL EVIDENCE FOR THE EXISTENCE OF 2 POOLS OF CELLULAR INOSITOL", European neuropsychopharmacology, 4(4), 1994, pp. 463-467

Abstract

Lithium reduces brain inositol levels by inhibiting inositol monophosphatase. In a previous study it was found that administration of pilocarpine to Li-treated rats causes limbic seizure behavior which can be reversed by i.c.v. myo-inositol but not chiro-inositol, suggesting that this behavior is related to inositol depletion in the PI cycle. Hyponatremia can lower brain inositol and hypernatremia can raise brain inositol. We now report that induction of low brain inositol by hyponatremia followed by pilocarpine did not cause limbic seizures. Induction of high brain inositol using hypernatremia followed by Li-pilocarpine administration did not reverse limbic seizures. These data support theconcept that inositol available for PI synthesis and inositol for osmotic function are sequestered in different cellular pools.

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Documento generato il 14/08/20 alle ore 16:27:25