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Titolo:
BETA-ADRENERGIC EFFECTS ON LEFT-VENTRICULAR FILLING - INFLUENCE OF AGING AND EXERCISE TRAINING
Autore:
STRATTON JR; LEVY WC; SCHWARTZ RS; ABRASS IB; CERQUEIRA MD;
Indirizzi:
VET AFFAIRS MED CTR,DEPT MED,DIV CARDIOL,1660 S COLUMBIAN WAY SEATTLEWA 98108 VET AFFAIRS MED CTR,DEPT MED,DIV GERONTOL SEATTLE WA 98108 VET AFFAIRS MED CTR,DEPT MED,DIV GERIATR MED SEATTLE WA 98108 UNIV WASHINGTON SEATTLE WA 98108
Titolo Testata:
Journal of applied physiology
fascicolo: 6, volume: 77, anno: 1994,
pagine: 2522 - 2529
SICI:
8750-7587(1994)77:6<2522:BEOLF->2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-STIMULATION; INDUCED LIPOLYSIS; HEART-RATE; AGE; HUMANS; REST; RELAXATION; ISOPRENALINE; EPINEPHRINE; PRESSURE;
Keywords:
BETA-ADRENERGIC RESPONSES; DIASTOLE; ISOPROTERENOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Stratton et al., "BETA-ADRENERGIC EFFECTS ON LEFT-VENTRICULAR FILLING - INFLUENCE OF AGING AND EXERCISE TRAINING", Journal of applied physiology, 77(6), 1994, pp. 2522-2529

Abstract

Reduced heart rate and contractile responses to beta-agonist stimulation characterize normal cardiac aging, but whether diastolic responsesalso decline with aging has not been determined in humans. Diastolic filling responses to isoproterenol were determined in 13 older (60-82 yr) and 11 young (24-32 yr) healthy men before and after endurance training. Filling rates were expressed in three ways: 1) normalized to end-diastolic volume per second, 2) normalized to stroke volume per second, and 3) as absolute milliliters of blood (ml.s(-1).m(-2)). Peak early filling rates by all methods were reduced at rest and all isoproterenol doses with aging (all P < 0.0001 for old vs. young), whereas peakatrial filling rates were increased with aging. During isoproterenol,both peak early and peak atrial filling rates increased significantly(all P < 0.01); the increase in filing rates with isoproterenol was not different with aging (all NS for old vs. young X dose). Endurance training did not augment diastolic filling responses to isoproterenol. Although diastolic filling rates at rest are markedly altered by aging, diastolic filling responses to isoproterenol are not reduced with aging. Thus the age-associated declines in heart rate, ejection fraction, and cardiac output responses to beta-adrenergic stimulation with isoproterenol do not extend to diastolic filling responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 10:30:33