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Titolo:
ENDOTHELIN EXPRESSION IN NORMAL HUMAN ANTERIOR PITUITARIES AND PITUITARY-ADENOMAS
Autore:
LANGE M; PAGOTTO U; HOPFNER U; EHRENREICH H; OECKLER R; SINOWATZ F; STALLA GK;
Indirizzi:
MAX PLANCK INST PSYCHIAT,INST CLIN,KRAEPELINSTR 10 D-80804 MUNICH GERMANY MAX PLANCK INST PSYCHIAT,INST CLIN D-80804 MUNICH GERMANY UNIV HEIDELBERG,HOSP MANNHEIM,DEPT NEUROSURG MANNHEIM GERMANY UNIV GOTTINGEN,DEPT NEUROL W-3400 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT PSYCHIAT W-3400 GOTTINGEN GERMANY UNIV MUNICH,INST VET ANAT MUNICH GERMANY
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 6, volume: 79, anno: 1994,
pagine: 1864 - 1870
SICI:
0021-972X(1994)79:6<1864:EEINHA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; MONOCLONAL-ANTIBODY KI-67; GROWTH-FACTOR; C-FOS; CHROMOSOMAL ASSIGNMENT; PROLACTIN-RELEASE; DNA-SYNTHESIS; SECRETION; RECEPTORS; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Lange et al., "ENDOTHELIN EXPRESSION IN NORMAL HUMAN ANTERIOR PITUITARIES AND PITUITARY-ADENOMAS", The Journal of clinical endocrinology and metabolism, 79(6), 1994, pp. 1864-1870

Abstract

Endothelins (ETs) ale important regulators of growth and function in many endocrine tissues. This study was designed to verify the expression of ETs in a series of normal human pituitaries and pituitary adenomas. We examined 13 normal pituitaries and 58 pituitary adenomas for the presence of immunoreactive (ir) ET-1 and ET-3. No ir-ET-1 was detected in any of the 13 normal pituitaries, whereas ir-ET-3 was observed in 4 of 13 (31%) cases. In contrast, 48% (28 of 58) of pituitary adenomas display immunoreactivity for ET-1, whereas 31% (18 of 58) show immunoreactivity for ET-3. With respect to the type of tumors, staining was as follows: nonfunctioning adenomas: ET-1, 14 of 33; ET-3, 9 of 33; somatotropinomas: ET-1, 8 of 16; ET-3, 6 of 16; corticotropinomas: ET-1, 5 of 5; ET-3, 2 of 5; and prolactinomas: ET-1, 1 of 4; ET-3, 1 of 4. Using double immunostaining, we found the colocalization of ET-3 in normal pituitaries and of ET-1 and ET-3 in pituitaries adenomas in each hormone-secreting cell. In Cushing adenomas, ET-1 was coexpressed incorticotropic cells in all 5 cases (100%). In the same tumors, by reverse transcriptase polymerase chain reaction, we investigated the presence of ET-1 and ET-3 messenger ribonucleic acids and found that they are expressed, respectively, in 18 of 21 and 7 of 11 tumors examined. Our findings demonstrate that pituitary adenomas frequently display ET-1 as well as ET-3 immunoreactivity, in contrast to normal pituitaries, in which only ET-3 was found. We showed the intratumoral presence ofET messenger ribonucleic acids, which indicates the production by tumor itself, rather than passive uptake or binding of ET peptide synthesized elsewhere.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:16:37