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Titolo:
PROCALCITONIN INCREASE AFTER ENDOTOXIN INJECTION IN NORMAL SUBJECTS
Autore:
DANDONA P; NIX D; WILSON MF; ALJADA A; LOVE J; ASSICOT M; BOHUON C;
Indirizzi:
SUNY BUFFALO,MILLARD FILLMORE HOSP,DEPT MED,3 GATES CIRCLE BUFFALO NY14209 SUNY BUFFALO,MILLARD FILLMORE HOSP,DEPT CLIN PHARMACOKINET BUFFALO NY14209 INST GUSTAVE ROUSSY,DEPT BIOL CLIN F-94805 VILLEJUIF FRANCE
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 6, volume: 79, anno: 1994,
pagine: 1605 - 1608
SICI:
0021-972X(1994)79:6<1605:PIAEII>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MEDULLARY CARCINOMA; MESSENGER-RNA; CALCITONIN; SERUM; ASSAY; SARCOIDOSIS; SEPSIS; INVIVO; BLOOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
P. Dandona et al., "PROCALCITONIN INCREASE AFTER ENDOTOXIN INJECTION IN NORMAL SUBJECTS", The Journal of clinical endocrinology and metabolism, 79(6), 1994, pp. 1605-1608

Abstract

As procalcitonin concentrations have been shown to be elevated in patients with septicemia and gram-negative infections in particular, we proceeded to investigate the effect of endotoxin, a product of gramnegative bacteria, on procalcitonin concentrations in normal human volunteers. Endotoxin from Escherichia coli 0113:H10:k, was injected iv at a dose of 4 mg/kg BW into these healthy volunteers. Blood samples were obtained before and 1, 2, 4, 6, 8, and 24 h after injection of the endotoxin. Each patient's cardiovascular and overall clinical status was monitored over this period. The patients developed chills and rigors, myalgia, and fever between 1-3 h. Tumor necrosis factor-cu levels increased sharply at 1 h and peaked at 90 min, reaching the baseline concentration thereafter by 6 h. Interleukin-6 levels increased more gradually, peaking at 3 h and reaching the baseline concentration at 8 h. Theprocalcitonin concentration, which was undetectable (<10 pg/mL) at 0,1, and 2 h, was detectable at 4 h and peaked at 6 h, maintaining a plateau through 8 and 24 h (4 ng/mL). There was no elevation of calcitonin concentrations, which remained below 10 pg/mL, the lowest sensitivity of the assay. Procalcitonin was measured by a two-antibody immunoradiometric assay specific for this peptide, with no cross-reactivity with calcitonin, katacalcin, or calcitonin gene-related peptide. We conclude that endotoxin induces the release of procalcitonin systemically,that this increase is not associated with an increase in calcitonin, and that the increase in procalcitonin associated with septicemia in patients may be mediated through the effect of endotoxin described here. Whether procalcitonin participates in the mechanisms underlying inflammation remains to be investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:25:39