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Titolo:
ISLET-CELL CYTOPLASMIC ANTIBODY REACTIVITY IN MIDGESTATIONAL HUMAN FETAL PANCREAS
Autore:
DEKRIJGER RR; VANKRUGTEN MV; KRANENBURG G; AANSTOOT HJ; MOLENAAR JL; BRUINING GJ;
Indirizzi:
ERASMUS UNIV ROTTERDAM,DEPT PEDIAT & CLIN GENET,DR MOLEWATERPLEIN 60 3015 GJ ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT PEDIAT & CLIN GENET 3015 GJ ROTTERDAM NETHERLANDS UNIV ROTTERDAM HOSP,SOPHIA CHILDRENS HOSP 3015 GJ ROTTERDAM NETHERLANDS SSDZ,DEPT CLIN IMMUNOL DELFT NETHERLANDS
Titolo Testata:
Acta diabetologica
fascicolo: 4, volume: 31, anno: 1994,
pagine: 232 - 235
SICI:
0940-5429(1994)31:4<232:ICARIM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; AUTOANTIBODIES; ANTIGEN; ASSAY;
Keywords:
ISLET CELL ANTIBODY; HUMAN FETAL PANCREAS; INDIRECT IMMUNOFLUORESCENCE; HUMORAL AUTOIMMUNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Dekrijger et al., "ISLET-CELL CYTOPLASMIC ANTIBODY REACTIVITY IN MIDGESTATIONAL HUMAN FETAL PANCREAS", Acta diabetologica, 31(4), 1994, pp. 232-235

Abstract

The reactivity of islet cell cytoplasmic antibodies (ICA)-positive and ICA-negative sera of recent onset type 1 diabetic patients was studied in human fetal pancreata of 12-18 weeks' gestation and compared with the reactivity of these sera in adult human control pancreata. The aims of the study were: (1) to observe the presence of ICA staining in human fetal islet cells; (2) to compare endpoint titres (in Juvenile Diabetes Foundation units) of ICA-positive patient sera in fetal pancreata and adult human control pancreata. Ten ICA-positive sera and eightICA-negative sera from newly diagnosed diabetic patients and four sera from healthy controls were tested on three human adult and eight human fetal pancreata. As in the adult control pancreata. ICA-positive sera reacted to insulin-, glucagon-, and somatostatin-positive cells of fetal pancreata of all gestational ages. This was observed both in single cells and in cells in islet-like cell clusters. Dilution of a reference serum gave similar results in both adult and fetal pancreata. Incontrast, the ICA-positive patient sera yielded a striking heterogeneity in fetal as well as in adult pancreata. However, end-point titres between adult and fetal pancreata did not differ significantly (P>0.05). In conclusion, ICA-positive sera from recent onset diabetic patients show that the expression of molecules to which ICA react is present in all islet cells and starts before week 12 of gestation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:18:38