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Titolo:
5-FLUOROURACIL CARDIOTOXICITY - A QUESTIO N OF FORMULATION
Autore:
LEMAIRE L; ARELLANO M; MALETMARTINO MC; MARTINO R; DEFORNI M;
Indirizzi:
UNIV TOULOUSE 3,IMRCP LAB,RMN BIOMED GRP,CNRS,URA 470,118 ROUTE NARBONNE F-31062 TOULOUSE FRANCE UNIV TOULOUSE 3,IMRCP LAB,RMN BIOMED GRP,CNRS,URA 470 F-31062 TOULOUSE FRANCE INST GUSTAVE ROUSSY F-77176 SAVIGNY TEMPLE FRANCE
Titolo Testata:
Bulletin du cancer
fascicolo: 12, volume: 81, anno: 1994,
pagine: 1057 - 1059
SICI:
0007-4551(1994)81:12<1057:5C-AQN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
FRE
Soggetto:
FLUOROURACIL;
Keywords:
FLUOROURACIL; CARDIOTOXICITY; F-19 NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
L. Lemaire et al., "5-FLUOROURACIL CARDIOTOXICITY - A QUESTIO N OF FORMULATION", Bulletin du cancer, 81(12), 1994, pp. 1057-1059

Abstract

The cardiotoxicity of 5-fluorouracil (FU) was attributed to degradation compounds present in the injected vials, fluoroacetaldehyde (Facet)and fluoromalonaldehydic acid (FMald). These compounds are formed withtime and the basic medium necessary to solubilize FU. FU-NaOH vials were much less cardiotoxic than FU-Tris vials on the isolated perfused rabbit heart model since, in FU-Tris vials, Facet and FMald are storedin stable ''depot'' forms, which are adducts with Tris, whereas, in FU-NaOH vials, they are extensively chemically transformed. Cardiotoxicfluoroacetate (FAG), arising from Facet metabolization, was found in urine of patients, with a ratio FAC/FU catabolites 10-30 fold lower inpatients treated with FU-NaOH than in those treated with FU-Tris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:34:10