Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRIMARY AND SECONDARY GENETIC RESPONSES AFTER FOLIC ACID-INDUCED ACUTE RENAL INJURY IN THE MOUSE
Autore:
CALVET JP; CHADWICK LJ;
Indirizzi:
UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL,3901 RAINBOW BLVD KANSAS CITY KS 66160
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 6, volume: 5, anno: 1994,
pagine: 1324 - 1332
SICI:
1046-6673(1994)5:6<1324:PASGRA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; POLYCYSTIC KIDNEY-DISEASE; SERUM-FREE MEDIUM; ORNITHINE DECARBOXYLASE; PROTOONCOGENE EXPRESSION; URETERAL OBSTRUCTION; MESSENGER-RNAS; FACTOR-ALPHA; CPK MOUSE; C-FOS;
Keywords:
EPIDERMAL GROWTH FACTOR; SULFATED GLYCOPROTEIN-2; ORNITHINE DECARBOXYLASE; PROTOONCOGENE; CYCLOHEXIMIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Calvet e L.J. Chadwick, "PRIMARY AND SECONDARY GENETIC RESPONSES AFTER FOLIC ACID-INDUCED ACUTE RENAL INJURY IN THE MOUSE", Journal of the American Society of Nephrology, 5(6), 1994, pp. 1324-1332

Abstract

Folic acid-induced acute renal injury results in dramatic changes in gene expression. Among the genes affected by folic acid treatment are the primary response genes, c-fos and c-myc, which are thought to function to initiate cell cycle events. In this report, changes in the expression of three other genes in response to folic acid injury have been investigated: ornithine decarboxylase, epidermal growth factor (EGF), and sulfated glycoprotein-2 (SGP-2). Renal injury was found to causea rapid decrease in EGF mRNA, which remained absent for several days after the initial injury, gradually returning to normal levels over anapproximately 3-wk regeneration and recovery period. Ornithine decarboxylase mRNA showed a similar decrease. In contrast, folio acid causeda rapid increase in SGP-2 mRNA, which peaked several days after treatment, decreasing to normal levels over the 3-wk period. The mRNAs for the primary response genes were superinduced in the injured kidneys inthe presence of the protein synthesis inhib itor cycloheximide. In contrast, the changes in EGF and SGP-2 mRNA levels were blocked by cycloheximide, indicating that these responses required new protein synthesis during the first few hours after folic acid injury. The opposite but parallel responses in the expression of the EGF and SGP-2 genes suggest that their regulation is coupled to the initial injury-induced dedifferentiation and subsequent return to the fully differentiated state.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 10:38:32