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Titolo:
PNEUMOCOCCAL BACTEREMIA AND SEPSIS IN CHI LDREN - A MULTICENTER STUDYIN FRANCE
Autore:
GRIMPREL E; FLORET D;
Indirizzi:
HOP ENFANTS ARMAND TROUSSEAU,26 AV DR ARNOLD NETTER F-75571 PARIS 12 FRANCE
Titolo Testata:
Medecine et maladies infectieuses
, volume: 24, anno: 1994,
pagine: 975 - 981
SICI:
0399-077X(1994)24:<975:PBASIC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
FRE
Keywords:
BACTEREMIA; STREPTOCOCCUS-PNEUMONIAE; RESISTANCE; PEDIATRICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
E. Grimprel e D. Floret, "PNEUMOCOCCAL BACTEREMIA AND SEPSIS IN CHI LDREN - A MULTICENTER STUDYIN FRANCE", Medecine et maladies infectieuses, 24, 1994, pp. 975-981

Abstract

Ninety-nine cases of pneumococcal bacteremia, recorded during year 1993 from 22 french pediatric hospitals, were retrospectively analysed. The incidence was estimated 0,47-4,3 p. 1000 blood cultures. Mean age was 3,5 years (range 0 days - 17,2 years); 56% were 3 months to 3 years old. Eleven children had immunosuppression. Only one patient was immunized with the 23-valent pneumococcal polysaccharide vaccine (splenectomy). A focus of infection was identified in 60 patients : among them, 16 had otitis media or sinusitis, 27 had a bronchopulmonary infection and 14 had meningitis 2 of which were diagnosed in a second time after admission. Among all isolates, 24,5% had reduced susceptibility to penicillin (MIC > 0,1 mg/l) and 14,3 % were resistant (MIC > 1 mg/l). Reduced susceptibility to penicillin was significantly higher in the region of Paris, in immunosuppressed patients and in case of previous treatment with a beta-lactam antibiotic. Resistance to other antibiotics was also tested : macrolides = 33,8%, streptogramines = 0,8%, trimethoprim-sulfamethoxazole = 27,6%, chloramphenicol = 28% and vancomycin = 0%. No difference in susceptibility was found with regard to the clinical presentation (fever of unknown origin, identified focus of infection). The six predominant serotypes (62% of the isolates) were, by decreasing frequency : 23, 14, 9, 6, 4, 19 and 1. Serotype 23 was linkedto a high degree of resistance (9 isolates/14). All but 3 patients recovered uneventfully, despite inadequate therapy for some of them. Three patients died; all had acute or relapsing leukemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:34:53