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Titolo:
ROLE OF ACTIVE CHANGES IN VENOUS CAPACITY BY THE CAROTID BAROREFLEX -ANALYSIS WITH A MATHEMATICAL-MODEL
Autore:
URSINO M; ANTONUCCI M; BELARDINELLI E;
Indirizzi:
UNIV BOLOGNA,DIPARTIMENTO ELETTR INFORMAT & SISTEMIST,VIALE RISORGIMENTO 2 I-40136 BOLOGNA ITALY UNIV BOLOGNA,DEPT ELECTR I-40136 BOLOGNA ITALY
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 6, volume: 36, anno: 1994,
pagine: 80002531 - 80002546
SICI:
0363-6135(1994)36:6<80002531:ROACIV>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINUS BARORECEPTOR REFLEX; SYSTEMIC VASCULAR BED; PERIPHERAL RESISTANCE; DOG; FLOW;
Keywords:
SHORT-TERM CARDIOVASCULAR HOMEOSTASIS; CAROTID SINUS BAROREFLEX; CARDIAC OUTPUT; ACUTE BLOOD HEMORRHAGE; CAPACITY CONTROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Ursino et al., "ROLE OF ACTIVE CHANGES IN VENOUS CAPACITY BY THE CAROTID BAROREFLEX -ANALYSIS WITH A MATHEMATICAL-MODEL", American journal of physiology. Heart and circulatory physiology, 36(6), 1994, pp. 80002531-80002546

Abstract

To elucidate the role of venous capacity active changes in short-termcardiovascular homeostasis, a mathematical model of the carotid-sinusbaroreflex system has been developed. In the model the cardiovascularsystem is represented as the series arrangement of six lumped compartments, which synthesize the fundamental hemodynamic properties of the systemic arterial, systemic venous, pulmonary arterial, and pulmonary venous circulations as well as of the left and right cardiac volumes. Cardiac outputs from the left and right ventricles are computed as a function of both downstream arterial pressure (afterload) and upstream atrial pressure (preload). Four distinct feedback regulatory mechanisms, working on systemic arterial resistance, heart rate, systemic venous unstressed volume, and systemic venous compliance, are assumed to operate on the cardiovascular system in response to carotid sinus pressure changes. All model parameters, both in the cardiovascular system and in feedback regulatory mechanisms, have been assigned on the basis of physiological data now available. The model is used here to simulatethe pattern of the main hemodynamic quantities in the short time period (1-2 min) after acute carotid sinus activation in vagotomized subjects. Simulation results indicate that the model can reproduce experimental data quite well, with reference both to open-loop experiments andto an acute blood hemorrhage performed in closed-loop conditions. Moreover, computer simulations indicate that active changes in venous unstressed volume are of primary importance in regulating cardiac output and systemic arterial pressure during activation of the carotid sinus baroreflex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:12:10