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Titolo:
INCREASED LEVELS OF SOLUBLE SERUM INTERLEUKIN-2 RECEPTOR IN EXTRINSICALLERGIC ALVEOLITIS CORRELATE WITH INTERLEUKIN-2 RECEPTOR EXPRESSION ON ALVEOLAR MACROPHAGES
Autore:
PFORTE A; BRUNNER A; GAIS P; STROBEL M; BURGER G; BREYER G; HAUSSINGER K; ZIEGLERHEITBROCK L;
Indirizzi:
UNIV MUNICH,KLINIKUM INNENSTADT,DEPT INTERNAL MED,ZIEMSSENSTR 1 W-8000 MUNICH 2 GERMANY GESELL STRAHLEN & UMWELTFORSCH MBH MUNICH GERMANY DEPT BIOMED IMAGE ANAL MUNICH GERMANY UNIV MUNICH,INST IMMUNOL W-8000 MUNICH GERMANY CENT HOSP GAUTING MUNICH GERMANY
Titolo Testata:
Journal of allergy and clinical immunology
fascicolo: 6, volume: 94, anno: 1994,
parte:, 1
pagine: 1057 - 1064
SICI:
0091-6749(1994)94:6<1057:ILOSSI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; PULMONARY SARCOIDOSIS; HYPERSENSITIVITY PNEUMONITIS; BINDING-PROTEIN; BLOOD MONOCYTES; IL-2 RECEPTOR; B-CELLS; LYMPHOCYTES; GAMMA; GENE;
Keywords:
EXTRINSIC ALLERGIC ALVEOLITIS; IL-2 RECEPTOR ALVEOLAR MACROPHAGES; LYMPHOCYTES; SSIL-2 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
A. Pforte et al., "INCREASED LEVELS OF SOLUBLE SERUM INTERLEUKIN-2 RECEPTOR IN EXTRINSICALLERGIC ALVEOLITIS CORRELATE WITH INTERLEUKIN-2 RECEPTOR EXPRESSION ON ALVEOLAR MACROPHAGES", Journal of allergy and clinical immunology, 94(6), 1994, pp. 1057-1064

Abstract

In a group of 20 patients with extrinsic allergic alveolitis (10 withfarmer's lung, 9 with bird-breeder's lung, and 1 with humidifier's lung), we observed increased levels of soluble serum interleukin-2 receptor (ssIL-2R) with an average of 75.2 pmol (control group average, 40.6 pmol). Analysis of bronchoalveolar lavage cells by immunocytochemistry with a CD25 antibody revealed only a slight increase to 4.2% IL-2R cells among alveolar lymphocytes but a pronounced rise to 21.2% IL-2R + cells among alveolar macrophages. Furthermore, cytometry revealed a fourfold higher IL-2R expression on a per cell basis for alveolar macrophages as compared with alveolar lymphocytes. A clear-cut positive correlation (p = 0.006) was found for ssIL-2R and IL-2R + alveolar macrophages, but only a borderline correlation was found for sslL-2R and IL-2R + alveolar lymphocytes (p = 0.04). The finding of a concomitant decrease of IL-2R + alveolar macrophages and of sslL-2R on allergen avoidance further supports the notion that alveolar macrophages may be the main source of the increased sslL-2R in patients with extrinsic allergic alveolitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:32:13