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Titolo:
RELATION OF SMOKING WITH CAROTID-ARTERY WALL THICKNESS AND STENOSIS IN OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY
Autore:
TELL GS; POLAK JF; WARD BJ; KITTNER SJ; SAVAGE PJ; ROBBINS J;
Indirizzi:
UNIV WASHINGTON,CHS COORDINATING CTR,DEPT BIOSTAT,CENTURY SQ,SUITE 2025,1501 4TH AVE SEATTLE WA 98101 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI,EPIDEMIOL SECT WINSTON SALEM NC 27103 BRIGHAM & WOMENS HOSP,DEPT RADIOL BOSTON MA 02115 UNIV MARYLAND,DEPT NEUROL BALTIMORE MD 21201 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV CALIFORNIA DAVIS,DEPT MED SACRAMENTO CA 00000
Titolo Testata:
Circulation
fascicolo: 6, volume: 90, anno: 1994,
pagine: 2905 - 2908
SICI:
0009-7322(1994)90:6<2905:ROSWCW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-MODE ULTRASOUND; CIGARETTE-SMOKING; RISK-FACTORS; ATHEROSCLEROSIS; MEN; ARTERIOSCLEROSIS; DISEASE;
Keywords:
ATHEROSCLEROSIS; STENOSIS; SMOKING; CAROTID ARTERIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
G.S. Tell et al., "RELATION OF SMOKING WITH CAROTID-ARTERY WALL THICKNESS AND STENOSIS IN OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY", Circulation, 90(6), 1994, pp. 2905-2908

Abstract

Background Cigarette smoking has been associated with increased risk of atherosclerotic diseases in hospital-based studies and in studies of middle-aged populations but not in population-based studies of olderadults with and without clinical cardiovascular disease. Methods and Results We investigated the relation of smoking to carotid artery atherosclerotic disease, expressed as intimal-medial wall thickness and arterial lumen narrowing (stenosis) measured by ultrasound. Subjects were 5116 older adults participating in the baseline examination of the Cardiovascular Health Study, a community-based study of cardiovascular diseases in older age. With increased smoking there was significantly greater internal and common carotid wall thickening and internal carotid stenosis: current smokers>former smokers>never-smokers; for instance, the unadjusted percent stenosis was 24%, 20%, and 16%, respectively(P<.0001). A significant dose-response relation was seen with pack-years of smoking. These findings persisted after adjusting for other cardiovascular risk factors and were also confirmed when analyses were restricted to those without prevalent cardiovascular disease. The difference in internal carotid wall thickness between current smokers and nonsmokers was greater than the difference associated with 10 years of age among never-smoking participants (0.39 mm versus 0.31 mm). Among all participants, the prevalence of clinically significant (greater thanor equal to 50%) internal carotid stenosis increased from 4.4% in never-smokers to 7.3% in former smokers to 9.5% in current smokers (P<.0001). Conclusions These findings extend previous reports of a positive relation between smoking and carotid artery disease to a population-based sample of older adults using several different indicators of atherosclerotic disease.

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Documento generato il 29/11/20 alle ore 14:32:28