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Titolo:
ABNORMAL DIURNAL-VARIATION OF BLOOD-PRESSURE, CARDIAC-OUTPUT, AND VASCULAR-RESISTANCE IN CARDIAC TRANSPLANT RECIPIENTS
Autore:
IDEMA RN; VANDENMEIRACKER AH; BALK AHMM; BOS E; SCHALEKAMP MADH; TVELD AJMI;
Indirizzi:
UNIV HOSP DIJKZIGT,CARDIOVASC RES INST COEUR,DEPT INTERNAL MED 1,ROOMCA 332 3015 GD ROTTERDAM NETHERLANDS UNIV HOSP DIJKZIGT,CARDIOVASC RES INST COEUR,DEPT INTERNAL MED 1 3015GD ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,UNIV HOSP DIJKZIGT,THORAXCTR ROTTERDAM NETHERLANDS
Titolo Testata:
Circulation
fascicolo: 6, volume: 90, anno: 1994,
pagine: 2797 - 2803
SICI:
0009-7322(1994)90:6<2797:ADOBCA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR HYPERTROPHY; HEART-RATE; SYMPATHETIC REINNERVATION; ESSENTIAL-HYPERTENSION; SYSTEM; CYCLOSPORINE; RHYTHM;
Keywords:
TRANSPLANTATION; BLOOD PRESSURE; CARDIAC OUTPUT; CYCLOSPORINE; PREDNISONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R.N. Idema et al., "ABNORMAL DIURNAL-VARIATION OF BLOOD-PRESSURE, CARDIAC-OUTPUT, AND VASCULAR-RESISTANCE IN CARDIAC TRANSPLANT RECIPIENTS", Circulation, 90(6), 1994, pp. 2797-2803

Abstract

Background An attenuated or absent nocturnal decline in blood pressure has repeatedly been documented in cardiac transplant recipients. Thepresent study was aimed at investigating the hemodynamic mechanism underlying this abnormality. Methods and Results In 23 cardiac transplant recipients (11 to 36 months after transplantation) and in 23 controlsubjects matched for age and 24-hour mean arterial pressure, invasive24-hour ambulatory blood pressure was measured by means of the Oxfordtechnique. Beat-to-beat relative values of stroke volume were determined by means of a pulse-contour method, and relative changes of cardiac output (stroke volumeXheart rate) and total peripheral vascular resistance (blood pressure/cardiac output) over the 24-hour period were calculated. The nocturnal decline in blood pressure was 20+/-8% (mean+/-SD) in control subjects but only 5+/-9% (P<.001) in cardiac transplantrecipients. In control subjects, the nocturnal decline in blood pressure was associated with a nocturnal fall in cardiac output of 24+/-13%, whereas vascular resistance compared with daytime value did not change. The small nocturnal decline in blood pressure in cardiac transplant recipients was associated with an attenuated nocturnal fall in cardiac output of 14+/-12% (P<.05 versus control subjects). In addition, vascular resistance compared with daytime value was increased by 9+/-9% (P<.05) during the night. Both in cardiac transplant recipients and incontrol subjects, the nocturnal changes in blood pressure were correlated with the nocturnal changes in cardiac output but not with the nocturnal changes in total peripheral vascular resistance. Conclusions This study confirms the attenuated nocturnal fall in blood pressure in cardiac transplant recipients. Hemodynamically, this attenuated blood pressure decline is characterized by a reduced nocturnal fall in cardiac output, and it is associated with a nocturnal increase in vascular resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:12:40