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Titolo:
GLUCOSE-METABOLISM IN THE CORTICAL AND SUBCORTICAL BRAIN STRUCTURES IN MULTIPLE SYSTEM ATROPHY AND PARKINSONS-DISEASE - A POSITRON EMISSIONTOMOGRAPHIC STUDY
Autore:
OTSUKA M; ICHIYA Y; KUWABARA Y; HOSOKAWA S; SASAKI M; YOSHIDA T; FUKUMURA T; KATO M; MASUDA K;
Indirizzi:
KYUSHU UNIV,DEPT RADIOL,MED INST BIOREGULAT,4546 TSURUMIHARA BEPPU OITA 874 JAPAN KYUSHU UNIV,FAC MED,DEPT RADIOL FUKUOKA 81282 JAPAN KYUSHU UNIV,FAC MED,DEPT NEUROL FUKUOKA 81282 JAPAN KYUSHU UNIV,FAC MED,DEPT CLIN NEUROPHYSIOL FUKUOKA 81282 JAPAN
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1-2, volume: 144, anno: 1996,
pagine: 77 - 83
SICI:
0022-510X(1996)144:1-2<77:GITCAS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
F-18 DOPA UPTAKE; STRIATONIGRAL DEGENERATION; HYPOMETABOLISM; PET;
Keywords:
MULTIPLE SYSTEM ATROPHY; PARKINSONS DISEASE; POSITRON EMISSION TOMOGRAPHY; GLUCOSE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Otsuka et al., "GLUCOSE-METABOLISM IN THE CORTICAL AND SUBCORTICAL BRAIN STRUCTURES IN MULTIPLE SYSTEM ATROPHY AND PARKINSONS-DISEASE - A POSITRON EMISSIONTOMOGRAPHIC STUDY", Journal of the neurological sciences, 144(1-2), 1996, pp. 77-83

Abstract

The brain glucose metabolism was studied by PET with F-18-FDG in 11 patients with multiple system atrophy (MSA) and 12 patients with idiopathic Parkinson's disease (PD). Seven of the 11 MSA patients were diagnosed as having olivopontocerebellar atrophy, two had striaronigral degeneration, while two demonstrated Shy-Drager syndrome. The glucose metabolic rates for each region in the PD patients showed no difference from the normal controls. The frontal, temporal and parietal cortical glucose metabolic rates and the caudate, the putaminal, the cerebellar and the brainstem glucose metabolic rates in the MSA patients decreased significantly from the controls. The atrophy of the cerebellum and the brainstem in the MSA patients were scored by MRI. The cerebellar and brainstem glucose metabolism in the MSA patients decreased as the atrophy score in such regions advanced in each group; however, some patients with no atrophy showed a decreased glucose metabolism. Although the cerebellar and the brainstem glucose metabolism decreased in all MSA patients, such a decrease was not observed in the SND patients, The decrease in the glucose metabolism for the non-cortical regions in theMSA patients seems to be due to a diffuse depletion of the neurons not restricted to the nigrostriatal neurons. Deafferentation to the cerebral cortices seems to result in a decreased cortical metabolism. The differences in the glucose metabolism between MSA and PD as assessed by PET may be caused by the pathophysiological differences between MSA and PD, and such differences therefore appear to be useful when makinga differential diagnosis between MSA and PD. The relative sparing of the brainstem and cerebellar glucose metabolism is considered to be a feature of patients with SND.

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Documento generato il 30/03/20 alle ore 00:45:14