Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CIRCULATORY ALTERATIONS INDUCED BY INTRAARTERIAL INJECTION OF IODIZEDOIL AND EMULSIONS OF IODIZED OIL AND DOXORUBICIN - EXPERIMENTAL-STUDY
Autore:
DEBAERE T; DUFAUX J; ROCHE A; COUNNORD JL; BERTHAULT MF; DENYS A; PAPPAS P;
Indirizzi:
INST GUSTAVE ROUSSY,DEPT INTERVENT RADIOL,39 RUE CAMILLE DESMOULINS F-94805 VILLEJUIF FRANCE UNIV PARIS,BIORHEOL & PHYSIOCOCHEM HYDRODYNAM LAB PARIS FRANCE
Titolo Testata:
Radiology
fascicolo: 1, volume: 194, anno: 1995,
pagine: 165 - 170
SICI:
0033-8419(1995)194:1<165:CAIBII>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCELLULAR-CARCINOMA; BLOOD-VESSELS; LIVER; BIODISTRIBUTION; MICROSCOPY; METASTASES; LIPIODOL; TUMORS; MUSCLE;
Keywords:
CONTRAST MEDIA, FATTY ACID; DOXORUBICIN; HEPATIC ARTERIES, THERAPEUTIC BLOCKADE; LIVER NEOPLASMS, CHEMOTHERAPEUTIC INFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
T. Debaere et al., "CIRCULATORY ALTERATIONS INDUCED BY INTRAARTERIAL INJECTION OF IODIZEDOIL AND EMULSIONS OF IODIZED OIL AND DOXORUBICIN - EXPERIMENTAL-STUDY", Radiology, 194(1), 1995, pp. 165-170

Abstract

PURPOSE: To evaluate circulatory alterations induced by intra-arterial injection of iodized oil and emulsions of iodized oil with an anticancer drug. MATERIALS AND METHODS: The viscosities and stability were evaluated in arterial flow of iodized oil and the emulsions. Doppler ultrasound was used to quantify the embolic effect in the arteries of rabbits. The behavior of doxorubicin and iodized oil in the rat cremaster muscle was studied with videomicroscopy. RESULTS: The emulsions did not break up after injection, and the size of discontinuous-phase droplets did not change. The embolic effect did not correlate with viscosity. The thinnest water-in-oil emulsion had the lowest embolic effect and induced homogeneous distribution of iodized oil droplets in the arterial tree. CONCLUSION: Changes in the formulation of emulsions obtained with the same proportions of drug and iodized oil change the distribution of iodized oil in the arterial tree, the location at which the drug is released, and the embolic effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 05:55:22