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Titolo:
THE RELATIONSHIP OF BLOOD-BORON AND URINE-BORON TO BORON EXPOSURE IN BORAX-WORKERS AND THE USEFULNESS OF URINE-BORON AS AN EXPOSURE MARKER
Autore:
CULVER BD; SHEN PT; TAYLOR TH; LEEFELDSTEIN A; ANTONCULVER H; STRONG PL;
Indirizzi:
UNIV CALIF IRVINE,COLL MED,ROOM 224,IRVINE HALL IRVINE CA 92717 US BORAX & CHEM CORP LOS ANGELES CA 00000
Titolo Testata:
Environmental health perspectives
, volume: 102, anno: 1994, supplemento:, 7
pagine: 133 - 137
SICI:
0091-6765(1994)102:<133:TROBAU>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BORIC-ACID; ELEMENTS; LITHIUM; TISSUES; RATS;
Keywords:
BORAX; BORON; EXPOSURE; BLOOD; URINE; AIR SAMPLING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
B.D. Culver et al., "THE RELATIONSHIP OF BLOOD-BORON AND URINE-BORON TO BORON EXPOSURE IN BORAX-WORKERS AND THE USEFULNESS OF URINE-BORON AS AN EXPOSURE MARKER", Environmental health perspectives, 102, 1994, pp. 133-137

Abstract

Daily dietary-boron intake and on-the-job inspired boron were compared with blood- and urine-boron concentrations in workers engaged in packaging and shipping borax. Fourteen workers handling borax at jobs of low, medium, and high dust exposures were sampled throughout full shifts for 5 consecutive days each. Airborne borax concentrations ranged from means of 3.3 mg/m(3) to 18 mg/m(3), measured gravimetrically. End-of-shift mean blood-boron concentrations ranged from 0.11 to 0.26 mu g/g; end-of-shift mean urine concentrations ranged from 3.16 to 10.72 mu g/mg creatinine. Creatinine measures were used to adjust for differences in urine-specific gravity such that 1 mt of urine contains approximately 1 mg creatinine. There was no progressive increase in end-of-shift blood- or urine-boron concentrations across the days of the week. Urine testing done al the end of the work shift gave a somewhat better estimate of berate exposure than did blood testing, was sampled moreeasily, and was analytically less difficult to perform. Personal air samplers of two types were used: one, the 37-mm closed-face, two-piececassette to estimate total dust and the other, the institute of Occupational Medicine (IOM) sampler to estimate inspirable particulate mass. Under the conditions of this study, the IOM air sampler more nearly estimated human exposure as measured by blood- and urine-boron levels than did the sampler that measured total dust. The highest mean blood-and urine-boron levels in the workers were approximately an order of magnitude lower than blood and urine values found by others in dogs during feeding studies conducted as part of reproductive toxicity studies at the no-observed-adverse-effect level (NOAEL). The mean dietary intake of the workers was 1.35 mg boron/day. close to the 1.521 mg boron/day reported recently for the standard U.S. diet. Total estimated boron intake, which is diet plus environmental exposure, had for the high-borax dust exposure group a mean daily boron intake of 27.90 mg/day or, based on the body weights of the subjects. 0.38 mg boron/kg/day. These subjects had a mean blood-boron level of 0.26 mu g boron/g blood, a factor of 10 lower than found in the dog or rat at NOAEL exposure levels.

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Documento generato il 01/12/20 alle ore 16:27:44