Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NITRAZEPAM IN PATIENTS WITH SLEEP-APNEA - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY
Autore:
HOIJER U; HEDNER J; EJNELL H; GRUNSTEIN R; ODELBERG E; ELAM M;
Indirizzi:
FROLUNDA SPECIALIST HOSP,DEPT OTORHINOLARYNGOL,BOX 138 S-42122 FROLUNDA SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT CLIN PHARMACOL S-41345 GOTHENBURGSWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT OTORHINOLARYNGOL S-41345 GOTHENBURG SWEDEN GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT CLIN NEUROPHYSIOL S-41345 GOTHENBURG SWEDEN
Titolo Testata:
The European respiratory journal
fascicolo: 11, volume: 7, anno: 1994,
pagine: 2011 - 2015
SICI:
0903-1936(1994)7:11<2011:NIPWS->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AROUSAL RESPONSE; AIRWAY OCCLUSION; APNEA SYNDROME; MIDAZOLAM; ALCOHOL; ETHANOL; GABA; BENZODIAZEPINE; FLURAZEPAM; TRIAZOLAM;
Keywords:
NITRAZEPAM; OXYGEN SATURATION; SLEEP APNEA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
U. Hoijer et al., "NITRAZEPAM IN PATIENTS WITH SLEEP-APNEA - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY", The European respiratory journal, 7(11), 1994, pp. 2011-2015

Abstract

We wanted to assess whether benzodiazepines worsen sleep apnoea, since their use in such patients has been controversial. Fourteen male patients with mild to moderate obstructive sleep apnoea were investigatedin a placebo-controlled, double-blind study evaluating the influence of nitrazepam (NIT) on apnoea frequency and severity. Each patient wasgiven oral nitrazepam 5 or 10 mg, or corresponding placebo, in a randomized order on three separate nights. Wash-out time was one week. A complete sleep study was undertaken at each study night. Eleven patients completed the study. Although there were individuals with marked variability in apnoea index between the three study nights, there was no significant change in apnoea index or minimum arterial oxygen saturation with any of the two nitrazepam dosages studied. Only 3 out of 11 patients had a higher apnoea index after both nitrazepam doses compared to placebo, and in these patients the increase in sleep-disordered. breathing was of marginal clinical significance. Nitrazepam caused a modest increase in total sleep time and a decrease in rapid eye movement (REM) sleep. These results demonstrate that nitrazepam does not worsensleep apnoea in patients with mild to moderate sleep apnoea. The previously reported sleep apnoea promoting effects of benzodiazepines may be restricted to a small subgroup of patients with sleep-disordered breathing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 18:58:36