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Titolo:
BRONCHOPROTECTION BY SALMETEROL - CELL STABILIZATION OR FUNCTIONAL ANTAGONISM - COMPARATIVE EFFECTS ON HISTAMINE-INDUCED AND AMP-INDUCED BRONCHOCONSTRICTION
Autore:
SOLER M; JOOS L; BOLLIGER CT; ELSASSER S; PERRUCHOUD AP;
Indirizzi:
UNIV BASEL HOSP,DEPT INTERNAL MED,DIV PULM CH-4031 BASEL SWITZERLAND
Titolo Testata:
The European respiratory journal
fascicolo: 11, volume: 7, anno: 1994,
pagine: 1973 - 1977
SICI:
0903-1936(1994)7:11<1973:BBS-CS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE-INDUCED BRONCHOCONSTRICTION; ASTHMATIC-PATIENTS; INHALED SALMETEROL; MEDIATOR RELEASE; RESPONSIVENESS; SALBUTAMOL; ALBUTEROL; ALLERGEN; AGONIST; LUNG;
Keywords:
ADENOSINE-5'-MONOPHOSPHATE; ASTHMA; BRONCHOPROTECTION; HISTAMINE; SALMETEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M. Soler et al., "BRONCHOPROTECTION BY SALMETEROL - CELL STABILIZATION OR FUNCTIONAL ANTAGONISM - COMPARATIVE EFFECTS ON HISTAMINE-INDUCED AND AMP-INDUCED BRONCHOCONSTRICTION", The European respiratory journal, 7(11), 1994, pp. 1973-1977

Abstract

Salmeterol provides bronchoprotection against a number of constrictorstimuli for more than 12 h after a single dose. This effect could be due either to functional antagonism at the level of airway smooth muscle or to cell-stabilizing effects of the compound. In this study, we attempted to clarify this mechanism by comparing the effects of salmeterol (50 mu g), salbutamol (200 mu g) and placebo on the airway responsiveness to histamine (to assess functional antagonism), and to adenosine 5'-monophosphate (AMP) (to assess additional cell-stabilizing effects), 14 h after drug treatment. Thirteen patients with mild allergic asthma were studied in a double-blind, randomized protocol on 6 days, at least 48 h apart, Forced expiratory volume in one second (FEV(1)) was measured before and 15 min after inhalation of the study medication. Then, 14 h later (8 a.m. the following morning), a bronchoprovocationtest with histamine or AMP was performed. We found that 14 h after inhalation, salmeterol still had a significant effect on FEV, in comparison to placebo and salbutamol. The provocative dose producing a 20% fall in FEV(1) (PD20 histamine) was significantly increased after salmeterol, whilst the increase in PD(20)AMP did not reach significance. Theshift in PD20 (in doubling dose steps) induced by salmeterol pretreatment was not different between histamine and AMP. We conclude that theprolonged protective effect of salmeterol occurs via an extended bronchodilating and functional antagonistic action and not via a cell-stabilizing effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:46:24