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Titolo:
GENETIC PREDISPOSITION TO HYPERLIPIDEMIA IN DIABETES - THE END OF THEBEGINNING
Autore:
WILSON DE; KWONG LK; ELBEIN SC; LALOUEL JM;
Indirizzi:
UNIV UTAH,SCH MED,HLTH SCI CTR,VET AFFAIRS MED CTR,DEPT INTERNAL MED SALT LAKE CITY UT 84132 UNIV UTAH,HOWARD HUGHES MED INST SALT LAKE CITY UT 00000 UNIV UTAH,DEPT HUMAN GENET SALT LAKE CITY UT 00000
Titolo Testata:
Journal of internal medicine
, volume: 236, anno: 1994, supplemento:, 736
pagine: 53 - 61
SICI:
0954-6820(1994)236:<53:GPTHID>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE GENE; APOLIPOPROTEIN-E POLYMORPHISM; MISSENSE MUTATION; DNA POLYMORPHISMS; E PHENOTYPE; HYPERTRIGLYCERIDEMIA; MELLITUS; HYPERLIPOPROTEINEMIA; TRIGLYCERIDE; FREQUENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Wilson et al., "GENETIC PREDISPOSITION TO HYPERLIPIDEMIA IN DIABETES - THE END OF THEBEGINNING", Journal of internal medicine, 236, 1994, pp. 53-61

Abstract

Diabetes mellitus leads to disturbances in lipoprotein homeostasis particularly when there is poor glycaemic control. The resulting abnormalities in concentration and composition of the circulating lipoproteins are modified by inherited variation in the genes coding for apolipoproteins, for the lipoprotein-processing enzymes, and possibly for lipoprotein receptors. Thus, poorly controlled diabetes provides an opportunity to observe the phenotypic effects of recessive mutant alleles that would otherwise be silent. This phenomenon should be considered when one attempts to understand the pathogenesis of variant phenotypes, ones differing from those typical of diabetes mellitus alone. Our understanding of how genetic variation modulates the expression of hyperlipidaemia in diabetes is still rudimentary-it now seems probable that many other genetic conditions affecting lipoprotein metabolism in diabetes will eventually be brought to light.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 06:31:43