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Titolo:
A JUNCTION-ORIFICE-FIBER ENTRANCE LAYER MODEL FOR CAPILLARY-PERMEABILITY - APPLICATION TO FROG MESENTERIC CAPILLARIES
Autore:
FU BM; WEINBAUM S; TSAY RY; CURRY FE;
Indirizzi:
CUNY CITY COLL,DEPT MECH ENGN NEW YORK NY 10031 CUNY CITY COLL,DEPT MECH ENGN NEW YORK NY 10031 NATL YANG MING MED COLL,INST BIOMED ENGN TAIPEI 11221 TAIWAN UNIV CALIF DAVIS,SCH MED,DEPT HUMAN PHYSIOL DAVIS CA 95616
Titolo Testata:
Journal of biomechanical engineering
fascicolo: 4, volume: 116, anno: 1994,
pagine: 502 - 513
SICI:
0148-0731(1994)116:4<502:AJELMF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GLYCOCALYX; PROTEINS; TRANSPORT; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
B.M. Fu et al., "A JUNCTION-ORIFICE-FIBER ENTRANCE LAYER MODEL FOR CAPILLARY-PERMEABILITY - APPLICATION TO FROG MESENTERIC CAPILLARIES", Journal of biomechanical engineering, 116(4), 1994, pp. 502-513

Abstract

The recent serial section electron microscopic studies by A damson and Michel ( 1993) on microves gets of frog mesentery have revealed thatthe large pores in the junction strand of the interendothelial cleft are widely separated 150 nm wide orifice-like breaks whose gap height 20 nm is the same as the wide part of the cleft. In this paper a modified version of the model in Weinbaum et al. (1992) is first developed in which this orifice structure is explored in combination with a random or ordered fiber matrix layer that is at the luminal surface and/oroccupies a fraction of the wide part of the cleft. This basic orificemodel predicts that for the measured L(p) to be achieved the fiber layer must be confined to a relatively narrow region at the entrance to the cleft where it serves as the primary molecular filter. The model provides a much better fit of the permeability P for intermediate size solutes between I and 2 nm radius than the previous model in Weinbaum et al., where the junction strand breaks were treated as finite depth circular or rectangular pores, but like the previous model significantly underestimates P for small ions. However, it is shown that Ifa small frequent pore of 1.5 nm radius with characteristic spacing comparable to the diameter of the junction proteins or a continuous narrow slitof approximately 1.5 to 2.3 nm gag height is also present in the continuous part of the junction strand, small ion permeability can also besatisfied. The 1.5 nm radius pore does not significantly change L(p),whereas the continuous narrow slit provides a contribution to L(p) that is comparable to, or in the case of the 2.3 nm slit greater than, the widely spaced 150 nm orifices. Thus, for the narrow slit the contribution to L from the orifices can be as low as 1.0x10(-7) cm/s/cm H2O and it is also possible to satisfy the 2.5 fold increase in permeability that occurs when the matrix is enzymatically removed from the luminal side of the cleft, Adamson (1990). The likelihood of each of these cleft structures is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:29:03