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Titolo:
THE ROLE OF BACTERIAL PROTEASES IN THE PATHOGENESIS OF CYSTIC-FIBROSIS
Autore:
SUTER S;
Indirizzi:
HOP CANTONAL UNIV GENEVA,HOP ENFANTS,30 BD CLUSE CH-1211 GENEVA 14 SWITZERLAND UNIV HOSP GENEVA,DEPT PEDIAT GENEVA SWITZERLAND
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 6, volume: 150, anno: 1994, supplemento:, S
pagine: 190000118 - 190000122
SICI:
1073-449X(1994)150:6<190000118:TROBPI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSEUDOMONAS-AERUGINOSA ELASTASE; PLASMA ALPHA-1-PROTEINASE INHIBITOR; BACTEROIDES-GINGIVALIS; STAPHYLOCOCCUS-AUREUS; LEUKOCYTE ELASTASE; ALKALINE PROTEASE; EXOTOXIN-A; INACTIVATION; SPUTUM; DEGRADATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S. Suter, "THE ROLE OF BACTERIAL PROTEASES IN THE PATHOGENESIS OF CYSTIC-FIBROSIS", American journal of respiratory and critical care medicine, 150(6), 1994, pp. 190000118-190000122

Abstract

Among the roles of mediators damaging the respiratory epithelium in patients with cystic fibrosis (CF)during the course of chronic, purulent bronchitis, that of neutrophil proteases is well established. The role of bacterial proteases is less well known. Among all pathogens colonizing the airways in CF, Pseudomonas aeruginosa is quantitatively thedominant pathogen; Staphylococcus aureus and Haemophilus influenzae are present in lower numbers. Anaerobic bacteria may be detected in numbers exceeding those of Staphylococcus aureus and Haemophilus influenzae. Among all enzymes secreted by these bacterial strains, Pseudomonaselastase and alkaline protease were shown to be secreted in vivo overprolonged periods in the airways. These enzymes, mainly elastase, have proteolytic activity on many proteins involved in host defense mechanisms, often the same as those hydrolyzed by neutrophil proteases. Pseudomonas elastase has damaging effects on the respiratory epithelium; it has recently also been shown to augment the permeability of the respiratory epithelium cultured in vitro by proteolytic attack of tight junctions. The potential role of proteases and other enzymes secreted by anaerobic bacteria has not been studied in this disease. In conclusion, bacterial proteases secreted in vivo may play a role in the pathogenesis of the airway disease in CF; their relative importance to the role of host proteases is, however, often difficult to determine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:28:09